{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T02:02:22Z","timestamp":1782698542139,"version":"3.54.5"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,22]],"date-time":"2006-01-22T00:00:00Z","timestamp":1137888000000},"content-version":"vor","delay-in-days":82,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p>Comparative study of the antiulcer and antisecretory activity of <jats:italic>Asparagus racemosus<\/jats:italic> Willd (Shatawari) and <jats:italic>Withania somnifera<\/jats:italic> Dunal (Ashwagandha) root extract with a standard drug, ranitidine, in various models of gastric ulcer in rats is presented. Ulcer was induced by the indomethacin (NSAID) and swim (restraint) stress treatment. Results demonstrated that <jats:italic>A. racemosus<\/jats:italic> as well as <jats:italic>W. somnifera<\/jats:italic> methanolic extract (100 mg\/kg BW\/day p.o.) given orally for 15 days significantly reduced the ulcer index, volume of gastric secretion, free acidity, and total acidity. A significant increase in the total carbohydrate and total carbohydrate\/protein ratio was also observed. Study also indicated an increase in antioxidant defense, that is, enzymes superoxide dismutase, catalase, and ascorbic acid, increased significantly, whereas a significant decrease in lipid peroxidation was observed. <jats:italic>A. racemosus<\/jats:italic> was more effective in reducing gastric ulcer in indomethacin\u2010treated gastric ulcerative rats, whereas <jats:italic>W. somnifera<\/jats:italic> was effective in stress\u2010induced gastric ulcer. Results obtained for both herbal drugs were comparable to those of the standard drug ranitidine.<\/jats:p>","DOI":"10.1196\/annals.1352.027","type":"journal-article","created":{"date-parts":[[2005,12,30]],"date-time":"2005-12-30T21:37:40Z","timestamp":1135978660000},"page":"261-278","source":"Crossref","is-referenced-by-count":75,"title":["Antiulcer and Antioxidant Activity of <i>Asparagus racemosus<\/i> WILLD and <i>Withania somnifera<\/i> DUNAL in Rats"],"prefix":"10.1111","volume":"1056","author":[{"given":"MAHEEP","family":"BHATNAGAR","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SIDDHRAJ S.","family":"SISODIA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"REKHA","family":"BHATNAGAR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,22]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1","article-title":"Acute effects of rantidine, famotidine and omneprazole on plasma gastrin in rats","volume":"249","author":"Decktor D.L.","year":"1989","journal-title":"J. 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