{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:39:47Z","timestamp":1784774387807,"version":"3.55.0"},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,9,7]],"date-time":"2006-09-07T00:00:00Z","timestamp":1157587200000},"content-version":"vor","delay-in-days":37,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract:\u2002<\/jats:sc><\/jats:bold>  <jats:bold>Pheochromocytoma (Pheo) is a rare cause of hypertension (HTN). Classically, a triad of symptoms includes sweating, palpitations, and headache. HTN is often present and labile. Although a triad of symptoms is cited as the most frequent presenting complaints, our clinical experience leads us to question how often these are present. Thirty\u2010two patients with histologically proven pheo or paraganglionoma were evaluated. Around 84.4% patients had adrenal pheos and 15.6% had extra\u2010adrenal pheos. Two patients had bilateral adrenal tumors, two had a history of prior pheos, and four had a family history of pheo. There were 19 (59.4%) female and 13 (40.6%) male patients. Six (18.7%) patients were black and 26 (81.3%) were white. The mean age at presentation was 43.2 \u00b1 13.9 years. Two patients were known to have neurofibromatosis type 1, two had von Hippel\u2013Lindau disease, one had multiple endocrine neoplasia 2A, and one PGL\/SDHD genetic mutation. Twenty\u2010six patients had sporadic tumors or had not had genetic testing. Biochemical diagnosis was confirmed with 24\u2010h urine measurements. Urine catecholamine measurements were elevated at least 2 to 4 times above normal levels. Mean SBP readings at presentation were 128 \u00b1 19 mmHg. Mean DBP readings were 81 \u00b1 13 mmHg. Around 65.6% patients were hypertensive at presentation. Fifty percent of the patients had palpitations, 40.6% had tachycardia, 34.4% had sweating, and 31.3% had headaches. Initial presenting symptoms were diverse. Pheo is a rare clinical entity and remains a huge diagnostic challenge for all clinicians.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1353.005","type":"journal-article","created":{"date-parts":[[2006,11,14]],"date-time":"2006-11-14T00:28:06Z","timestamp":1163464086000},"page":"47-51","source":"Crossref","is-referenced-by-count":24,"title":["Lack of Symptoms in Patients with Histologic Evidence of Pheochromocytoma"],"prefix":"10.1111","volume":"1073","author":[{"given":"DEBBIE L.","family":"COHEN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DOUGLAS","family":"FRAKER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RAYMOND R.","family":"TOWNSEND","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67139-5"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003450050102"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0013"},{"key":"e_1_2_5_5_2","volume-title":"Clinical and Experimental Pheochromocytoma","author":"Manger W.M.","year":"1996"},{"key":"e_1_2_5_6_2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0025-7125(16)30088-8","article-title":"Pheochromocytoma. Update on diagnosis, localization, and management","volume":"765","author":"Werbel S.S.","year":"1995","journal-title":"Med. Clin. N. Amer."},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1055-3207(18)30244-8"},{"key":"e_1_2_5_8_2","first-page":"354","article-title":"Prevalence of clinically suspected pheochromocytoma: review of a 50\u2010year autopsy series","volume":"56","author":"Sutton M.G.","year":"1981","journal-title":"Mayo Clin. Proc."}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1353.005","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1353.005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T19:35:54Z","timestamp":1695670554000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1353.005"}},"subtitle":["A Diagnostic Challenge"],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1196\/annals.1353.005"],"URL":"https:\/\/doi.org\/10.1196\/annals.1353.005","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}