{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:59:04Z","timestamp":1791035944649,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,3,29]],"date-time":"2006-03-29T00:00:00Z","timestamp":1143590400000},"content-version":"vor","delay-in-days":118,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> The complete genome sequences available for eight species of <jats:italic>Rickettsia<\/jats:italic> and information for other near relatives in the Rickettsiales including <jats:italic>Orientia<\/jats:italic> and species of Anaplasmataceae are a rich resource for comparative analyses of the evolution of these obligate intracellular bacteria. Differences in these organisms have permitted them to colonize varied intracellular compartments, arthropod vectors, and vertebrate reservoirs in both pathogenic and symbiotic relationships. We summarize some comparative aspects of the genomes of these organisms, paying particular attention to the recently completed sequence for <jats:italic>R. canadensis<\/jats:italic> McKiel strain and an estimated two\u2010thirds of the genome sequence for a Thailand patient isolate of <jats:italic>Orientia tsutsugamushi<\/jats:italic>. The <jats:italic>Rickettsia<\/jats:italic> genomes exhibit a high degree of synteny punctuated by distinctive chromosome inversions and consistent phylogenetic relationships regardless of whether protein coding sequences or RNA genes, concatenated open reading frames or gene regions, or whole genomes are used to construct phylogenetic trees. The aggregate characteristics (number, length, composition, repeat identity) of tandem repeat sequences of <jats:italic>Rickettsia<\/jats:italic>, which often exhibit recent and rapid divergence between closely related strains and species of bacteria, are also very conserved in <jats:italic>Rickettsia<\/jats:italic> but differed significantly in <jats:italic>Orientia<\/jats:italic>. <jats:italic>O. tsutsugamushi<\/jats:italic> shared no significant synteny to species of <jats:italic>Rickettsia<\/jats:italic> or Anaplasmataceae, supporting its placement in a unique genus. Like <jats:italic>Rickettsia felis, Orientia<\/jats:italic> has many transposases and ankyrin and tetratricopeptide repeat domains. <jats:italic>Orientia<\/jats:italic> shares the important ATP\/ADP translocase and proline\u2010betaine transporter multigene families with <jats:italic>Rickettsia<\/jats:italic>, but has more gene families that may be involved in regulatory and transporter responses to environmental stimuli.<\/jats:p>","DOI":"10.1196\/annals.1355.006","type":"journal-article","created":{"date-parts":[[2006,2,15]],"date-time":"2006-02-15T19:58:18Z","timestamp":1140033498000},"page":"47-63","source":"Crossref","is-referenced-by-count":38,"title":["New Perspectives on Rickettsial Evolution from New Genome Sequences of <i>Rickettsia<\/i>, particularly <i>R. canadensis<\/i>, and <i>Orientia tsutsugamushi<\/i>"],"prefix":"10.1111","volume":"1063","author":[{"given":"MARINA E.","family":"EREMEEVA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANUP","family":"MADAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRIS D.","family":"SHAW","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KEVIN","family":"TANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GREGORY A.","family":"DASCH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,29]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/24094"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5490.347"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1061471"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.17.5842-5855.2004"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0030248"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh254"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1139\/m67-065"},{"key":"e_1_2_8_9_2","unstructured":"Lane R.S. 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