{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:31:07Z","timestamp":1790901067069,"version":"4.1.0"},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,3,29]],"date-time":"2006-03-29T00:00:00Z","timestamp":1143590400000},"content-version":"vor","delay-in-days":118,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold>  <jats:italic>Orientia tsutsugamushi<\/jats:italic>, an obligate intracellular bacterium, is the causative agent of scrub typhus. The sequencing and analysis of full genomic DNA of <jats:italic>O. tsutsugamushi<\/jats:italic> has revealed at least 19 genes thus far encoding proteins with different numbers of ankyrin repeat domains. We have cloned several genes containing ankyrin repeats from the genome and produced fusion proteins to characterize their functions in host cells. It is likely that the proteins with ankyrin repeat domains expressed in <jats:italic>O. tsutsugamushi<\/jats:italic>\u2010infected cells may control the synthesis or stability of host proteins to modulate the various cellular functions after infection. The exploitation of host factors by ankyrin repeat proteins of <jats:italic>O. tsutsugamushi<\/jats:italic> may also play a critical role in its pathogenesis.<\/jats:p>","DOI":"10.1196\/annals.1355.016","type":"journal-article","created":{"date-parts":[[2006,2,15]],"date-time":"2006-02-15T19:58:18Z","timestamp":1140033498000},"page":"100-101","source":"Crossref","is-referenced-by-count":6,"title":["Molecular Characterization of a Group of Proteins Containing Ankyrin Repeats in <i>Orientia tsutsugamushi<\/i>"],"prefix":"10.1111","volume":"1063","author":[{"given":"NAM\u2010HYUK","family":"CHO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JO\u2010MIN","family":"KIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EUN\u2010KYUNG","family":"KWON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SE\u2010YOON","family":"KIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SEUNG\u2010HOON","family":"HAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HYUK","family":"CHU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JUNG\u2010HEE","family":"LEE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MYUNG\u2010SIK","family":"CHOI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IK\u2010SANG","family":"KIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,29]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(00)01352-6"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1110\/ps.03554604"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(99)01426-7"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2003.12.003"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0030248"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0931379100"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.9.5277-5283.2000"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-004-0088-2"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1355.016","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1355.016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:19:54Z","timestamp":1695687594000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1355.016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["10.1196\/annals.1355.016"],"URL":"https:\/\/doi.org\/10.1196\/annals.1355.016","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}