{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T11:57:31Z","timestamp":1718539051605},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,3,29]],"date-time":"2006-03-29T00:00:00Z","timestamp":1143590400000},"content-version":"vor","delay-in-days":118,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> Signaling interactions between vascular endothelium and invading rickettsiae provide a unique way of coordinating appropriate physiologic responses, which are important determinants of the ensuing pathogenesis mechanisms such as host defense and inflammation. Two major subgroups of pathogenic <jats:italic>Rickettsia<\/jats:italic> species, namely the typhus group (TG) and the spotted fever group (SFG), exhibit marked differences in their intracytoplasmic behavior. Using <jats:italic>in vitro<\/jats:italic> infection of cultured human endothelial cells with <jats:italic>R. rickettsii<\/jats:italic>, the causative agent of Rocky Mountain SF, we previously identified activation of NF\u2010\u03baB and p38 MAP kinase as essential components of intracellular signaling events responsible for <jats:italic>Rickettsia<\/jats:italic>\u2010induced transcriptional activation. Our data also suggest that p38 activity does not contribute to NF\u2010\u03baB response, implicating involvement of independent upstream signaling pathways. Since divergent cytopathologies suggest potentially different interactions with host cells, the aim of this study was to compare these responses after endothelial cell infection with <jats:italic>R. conorii<\/jats:italic>, the agent of Mediterranean SF, and a TG representative <jats:italic>R. typhi<\/jats:italic>, the agent of endemic typhus.<\/jats:p>","DOI":"10.1196\/annals.1355.030","type":"journal-article","created":{"date-parts":[[2006,2,15]],"date-time":"2006-02-15T19:58:18Z","timestamp":1140033498000},"page":"203-206","source":"Crossref","is-referenced-by-count":9,"title":["Similarities and Differences in Host Cell Signaling following Infection with Different <i>Rickettsia<\/i> Species"],"prefix":"10.1111","volume":"1063","author":[{"given":"ELENA","family":"RYDKINA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID J.","family":"SILVERMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SANJEEV K.","family":"SAHNI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3,29]]},"reference":[{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/381710"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2003.tb07424.x"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2003.12.003"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.00220"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.1.155-165.2005"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00574.x"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-47-2-252"},{"key":"e_1_2_3_9_2","unstructured":"Reference not provided."}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1355.030","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1355.030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:19:36Z","timestamp":1695687576000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1355.030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["10.1196\/annals.1355.030"],"URL":"https:\/\/doi.org\/10.1196\/annals.1355.030","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}