{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T03:14:36Z","timestamp":1783307676774,"version":"3.54.6"},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,3,29]],"date-time":"2006-03-29T00:00:00Z","timestamp":1143590400000},"content-version":"vor","delay-in-days":118,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> A truncated gene <jats:italic>ompA<\/jats:italic> was amplified from <jats:italic>Rickettsia heilongjiangensis<\/jats:italic> isolated in China and a 56\u2010kDa truncated OmpA protein was expressed in <jats:italic>E. coli<\/jats:italic> cells transformed with the <jats:italic>ompA<\/jats:italic>\u2010recombined expression plasmid. High levels of serum antibodies to <jats:italic>R. heilongjiangensis<\/jats:italic> and proliferation of the splenic cells were found in mice immunized with the truncated OmpA. After challenge with <jats:italic>R. heilongjiangensis<\/jats:italic> or <jats:italic>R. rickettsii<\/jats:italic>, fever and pathological damages of the guinea pigs immunized with the truncated OmpA were significantly slighter as compared with those of nonimmunized guinea pigs. These results suggest that the truncated OmpA of <jats:italic>R. heilongjiangii<\/jats:italic> is immunogenic for effectively inducing humoral and cell\u2010mediated immune responses against homologous and heterologous species in the spotted fever group.<\/jats:p>","DOI":"10.1196\/annals.1355.042","type":"journal-article","created":{"date-parts":[[2006,2,15]],"date-time":"2006-02-15T19:58:18Z","timestamp":1140033498000},"page":"261-265","source":"Crossref","is-referenced-by-count":17,"title":["Analysis of Immunoprotectivity of the Recombinant OmpA of <i>Rickettsia heilongjiangensis<\/i>"],"prefix":"10.1111","volume":"1063","author":[{"given":"YANMEI","family":"JIAO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BOHAI","family":"WEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MEILING","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DONGSHENG","family":"NIU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JUN","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LING","family":"QIU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,29]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"128","article-title":"Confirmation of patients with tick\u2010borne spotted fever caused by Rickettsia heilongjiangensis","volume":"10","author":"Lou D.","year":"1989","journal-title":"Chin. 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Hyg."}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1355.042","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1355.042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:21:08Z","timestamp":1695687668000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1355.042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["10.1196\/annals.1355.042"],"URL":"https:\/\/doi.org\/10.1196\/annals.1355.042","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}