{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T06:07:29Z","timestamp":1695708449340},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T00:00:00Z","timestamp":1137974400000},"content-version":"vor","delay-in-days":53,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p>The purpose of my report is to synthetically summarize the concept of the rotatory essence of the Whole and to bring evidence that while aging responds to a precise inner \u201cprogram\u201d of the mammalian and any other species' \u201cbrain,\u201d acceleration of aging and all diseases are simply the direct outcome of a desynchronization of our inner \u201cclock\u201d with respect to the precise periodicity and hormone\u2010integrated rhythmicity of the solar system. Those neuroendocrine, hormonal derangements of our inner clock are easily detectable and inevitably anticipate even by decades the onset of all diseases (autoimmune, cardiovascular, neurodegenerative, neoplastic). I will introduce those interventions capable of detecting early alterations and of restoring hormonal rhythmicity, which will consequently restore immunological surveillance in a positive cascade sequence.<\/jats:p>","DOI":"10.1196\/annals.1356.007","type":"journal-article","created":{"date-parts":[[2006,1,6]],"date-time":"2006-01-06T20:33:18Z","timestamp":1136579598000},"page":"1-15","source":"Crossref","is-referenced-by-count":0,"title":["The Rotational Origin and State of the Whole: Its Relation to Growth, Fertility, Aging, Death, and Diseases"],"prefix":"10.1111","volume":"1057","author":[{"given":"WALTER","family":"PIERPAOLI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,23]]},"reference":[{"key":"e_1_2_11_2_2","unstructured":"Jaffe A. 1972. From the Life and Work of C.G. Jung. English translation by R.F.C. Hull. Hodder & Stoughton. London."},{"key":"e_1_2_11_3_2","first-page":"99","article-title":"The pineal gland and melatonin: a circadian or seasonal aging clock","volume":"3","author":"Pierpaoli W.","year":"1991","journal-title":"Aging"},{"key":"e_1_2_11_4_2","unstructured":"Pierpaoli W.1994.The pineal aging clock. Evidence models and an approach to aging\u2010delaying strategies. In Aging Immunity and Infection. D.D. Powers J.E. Morley & R.M. Coe Eds.: 166\u2013175. Springer. New York."},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.2.787"},{"key":"e_1_2_11_6_2","unstructured":"Buddha. 1987. Thus have I heard page 46. Translated from the Pali by M. Walshe. A new translation of the Digha Nikaya. Wisdom Publications. London."},{"key":"e_1_2_11_7_2","unstructured":"Lacocque A. 1967. Le Devenir de Dieu page 100. Editions Universitaires. Paris."},{"key":"e_1_2_11_8_2","unstructured":"The New English Bible. 1970. Exodus 3:14. Page 63 and corresponding note. Oxford University Press. Oxford."},{"key":"e_1_2_11_9_2","unstructured":"Pierpaoli W.& C.X. Yi.1990.The pineal gland and melatonin: the aging clock? A concept and experimental evidence. In Stress and the Aging Brain. G. Nappi E. Martignoni A.R. Genazzani & F. Petraglia Eds.: 171\u2013175. Raven Press. New York."},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/00207459008999737"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2478(87)90169-6"},{"key":"e_1_2_11_12_2","first-page":"291","article-title":"The pineal control of aging","volume":"621","author":"Pierpaoli W.","year":"1991","journal-title":"The effects of melatonin and pineal grafting on the survival of older mice. Ann. N.Y. Sci."},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1994.tb56850.x"},{"key":"e_1_2_11_14_2","unstructured":"Pierpaoli W. W. Regelson & C. Colman. 1995. The Melatonin Miracle. Simon & Schuster. New York."},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90131-0"},{"key":"e_1_2_11_16_2","doi-asserted-by":"crossref","unstructured":"Turek F.W. Melatonin hype hard to swallow. 1996. Nature379:295\u2013296.","DOI":"10.1038\/379295a0"},{"key":"e_1_2_11_17_2","first-page":"31","article-title":"The pineal aging and death program","volume":"4","author":"Pierpaoli W.","year":"2001","journal-title":"I. Grafting of old pineals in young mice accelerates their aging. J. Anti-Aging Med."},{"key":"e_1_2_11_18_2","doi-asserted-by":"crossref","unstructured":"Pierpaoli W. & V.A. Lesnikov. 1997. Theoretical considerations on the nature of the pineal \u201cAging Clock.\u201d Gerontology43:20\u201325.","DOI":"10.1159\/000213833"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1994.tb39643.x"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(96)00163-5"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(00)00217-5"},{"key":"e_1_2_11_22_2","doi-asserted-by":"crossref","unstructured":"Fabris N. M.M. Markovic N.H. Spector & B.D. Jankovic Eds. 1994. Neuroimmunomodulation: The State of the Art. Ann. N.Y. Acad. Sci. Vol. 741.","DOI":"10.1111\/j.1749-6632.1994.tb23081.x"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/215834a0"},{"key":"e_1_2_11_24_2","first-page":"217","article-title":"Hormones and immunological capacity","volume":"16","author":"Pierpaoli W.","year":"1969","journal-title":"II. Reconstitution of antibody production in hormonally deficient mice by somatotropic hormone, thyrotropic hormone, and thyroxin. Immunology"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/240557a0"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/newbio238282a0"},{"key":"e_1_2_11_27_2","first-page":"323","article-title":"Role of the thymus in programming of neuroendocrine functions","volume":"20","author":"Pierpaoli W.","year":"1975","journal-title":"1975. Clin. Exp. Immunol."},{"key":"e_1_2_11_28_2","first-page":"501","article-title":"Interdependence of thymic and neuroendocrine functions in ontogeny","volume":"24","author":"Pierpaoli W.","year":"1976","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(77)90271-4"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01934028"},{"key":"e_1_2_11_31_2","unstructured":"Maestroni G.& W. Pierpaoli.1981.Pharmacological control of the hormonally mediated immune response. In Psychoneuroimmunology. R.A. Ader Ed.: 404\u2013428. Academic Press. New York."},{"key":"e_1_2_11_32_2","unstructured":"Pierpaoli W. Integrated phylogenetic and ontogenetic evolution of neuroendocrine and identity\u2010defense immune functions.InPsychoneuroimmunology. R.A. Ader Ed.: 575\u2013606. Academic Press. New York."},{"key":"e_1_2_11_33_2","doi-asserted-by":"crossref","unstructured":"Pierpaoli W. & D. Bulian. 2005. The pineal aging and death program. II. Life prolongation in pre\u2010aging pinealectomized mice. Ann. N.Y. Acad. Sci. In press.","DOI":"10.1196\/annals.1356.008"},{"key":"e_1_2_11_34_2","first-page":"405","article-title":"Prolonging the life span","volume":"39","author":"McCay C.M.","year":"1934","journal-title":"Sci. Monthly"},{"key":"e_1_2_11_35_2","unstructured":"Weindruch R. & R.L. Walford. 1988. The Retardation of Aging and Disease by Dietary Restriction. Charles C. Thomas Ed. Thomas. Springfield IL."},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-997-0004-2"},{"key":"e_1_2_11_37_2","unstructured":"Pierpaoli W. M. Haemmerli E. Sorkin & H. Hurni.1977.Role of thymus and hypothalamus in aging. In Fifth European Symposium on Basic Research in Gerontology. U.J. Schmidtet al. Eds.: 141\u2013150. Verlag Dr. Med. D. Straube. Erlangen Germany."},{"key":"e_1_2_11_38_2","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1210\/jcem.86.7.7655","article-title":"Dietary caloric restriction prevents the age\u2010related decline in plasma melatonin levels of Rhesus monkeys","volume":"86","author":"Roth S.G.","year":"2001","journal-title":"J. Clin. Endocrin. Metab."},{"key":"e_1_2_11_39_2","first-page":"456","article-title":"The pineal aging clock","volume":"719","author":"Pierpaoli W","year":"1994","journal-title":"Evidence, models, mechanisms, interventions. Ann. N.Y. Acad. Sci."},{"key":"e_1_2_11_40_2","first-page":"528","article-title":"Pineal control of stress, distress, and aging: the melatonin evidence","volume":"10","author":"Pierpaoli W.","year":"1997","journal-title":"Dev. Brain Dysfunct."},{"key":"e_1_2_11_41_2","unstructured":"Pierpaoli W.2005.Our endogenous \u201cpineal clock\u201d and cancer. Cancer and non\u2010cancer strategies for early detection prevention and cure of neoplastic processes. In Hormones Age and Cancer. L.M Berstein Ed.: 207\u2013225. Nauka. St. Petersburg."}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1356.007","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1356.007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T22:48:02Z","timestamp":1695682082000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1356.007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["10.1196\/annals.1356.007"],"URL":"https:\/\/doi.org\/10.1196\/annals.1356.007","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}