{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T09:10:05Z","timestamp":1792228205475,"version":"4.4.0"},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T00:00:00Z","timestamp":1153872000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract:\u2002<\/jats:sc><\/jats:bold>  <jats:bold>Although research indicates that hightened glucocorticoid levels impair long\u2010term memory functions and may inhibit traumatic memory retrieval in humans, the impact of acutely elevated glucocorticoid levels on learning and attentional functions is still unclear. Furthermore, the effect of glucocorticoids on executive functions as well as the recovery from long\u2010term memory deficits is insufficiently studied. The present study examined memory functions in patients with acute exacerbation of neurological diseases (multiple sclerosis, acute optic neuritis), who were treated with a high dose of glucocorticoids. All patients demonstrated a reversible impairment of long\u2010term memory functions, whereas measures of short\u2010term memory, attentional functions, and alertness remained unaffected. These findings indicate a selective cognitive disturbance, providing further evidence that the memory deficits reflect a receptor\u2010mediated effect of glucocorticoids on hippocampal function thereby supporting a potential association of stress\u2010induced elevated cortisol levels and memory disturbances in trauma\u2010related psychiatric disorders (psychogenic amnesia, PTSD).<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1364.037","type":"journal-article","created":{"date-parts":[[2006,8,5]],"date-time":"2006-08-05T01:56:13Z","timestamp":1154742973000},"page":"434-437","source":"Crossref","is-referenced-by-count":28,"title":["Effect of High\u2010Dose Cortisol on Memory Functions"],"prefix":"10.1111","volume":"1071","author":[{"given":"ROMUALD","family":"BRUNNER","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DANIELE","family":"SCHAEFER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KLAUS","family":"HESS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PETER","family":"PARZER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FRANZ","family":"RESCH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STEFAN","family":"SCHWAB","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,26]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1314.013"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(97)00004-0"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/73873"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000149523.35039.4C"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1998.tb05967.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.113.3.420"},{"key":"e_1_2_5_8_2","volume-title":"Test for Attentional Performance (TAP)","author":"Zimmermann P.","year":"1995"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1364.037","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1364.037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:40:15Z","timestamp":1695688815000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1364.037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1196\/annals.1364.037"],"URL":"https:\/\/doi.org\/10.1196\/annals.1364.037","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}