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PCOS represents a disorder that not only enhances the risk for type 2 diabetes (T2D) but is also associated with an increased number of cardiovascular risk factors known to facilitate atherogenesis. On the other hand, inflammation is thought to play an important role in the progression and development of complications of atherosclerosis. Evidence of low\u2010grade chronic inflammation in PCOS is indicated by the presence of elevated C\u2010reactive protein (CRP) levels, inflammatory cytokines (i.e., IL\u20106 and IL\u201018), and increased leucocyte count. CRP, a nonspecific marker of inflammation, has been proven to be one of the strongest predictors of the risk of cardiovascular events in patients with or without cardiovascular disease. The levels of the adhesion molecules (AM), sIVAM\u20101, sVCAM\u20101, and sE\u2010selectin in serum reflect low\u2010grade chronic inflammation of the endothelium and independently predict coronary heart disease (CHD) and T2D. In a recent study in a large number of PCOS women we demonstrated elevated levels of sIVAM\u20101 and sE\u2010selectin and we further substantiated the existence of a low\u2010grade chronic inflammatory process in PCOS. However, it remains to be assessed with long\u2010term studies whether the early presence of markers of chronic inflammation in young women with this syndrome has clinical significance.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1365.015","type":"journal-article","created":{"date-parts":[[2007,2,16]],"date-time":"2007-02-16T19:26:13Z","timestamp":1171653973000},"page":"175-186","source":"Crossref","is-referenced-by-count":94,"title":["Indices of Low\u2010Grade Inflammation in Polycystic Ovary Syndrome"],"prefix":"10.1111","volume":"1092","author":[{"given":"EVANTHIA","family":"DIAMANTI\u2010KANDARAKIS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"THOMAS","family":"PATERAKIS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HELEN A.","family":"KANDARAKIS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,31]]},"reference":[{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.11.6148"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.10.004"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-032049"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.18.6.774"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03111-4"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030334"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.15.7.821"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1500793"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.10.7904"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.02170.x"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.10.1410"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.8.1949"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408183310709"},{"key":"e_1_2_3_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.10.1104"},{"key":"e_1_2_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/154.8.758"},{"key":"e_1_2_3_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040967"},{"key":"e_1_2_3_18_2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2337\/diab.34.2.101","article-title":"Acanthosis nigricans in obese women with hyperandrogenism. 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