{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:03:11Z","timestamp":1792072991863,"version":"4.4.0"},"reference-count":80,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,1,31]],"date-time":"2007-01-31T00:00:00Z","timestamp":1170201600000},"content-version":"vor","delay-in-days":61,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract:\u2002<\/jats:sc><\/jats:bold>  <jats:bold>Human oocyte maturation is a long process during which nuclear maturation occurs resulting in germinal vesicle breakdown (transition from prophase I to metaphase II) and extrusion of the first polar body. During oocyte maturation, in parallel with nuclear maturation, a number of events take place in the oocyte cytoplasm that assist fertilization and early embryonic development. So far several attempts have been made to mature human oocytes <jats:italic>in vitro<\/jats:italic>. The main patient group to which <jats:italic>in vitro<\/jats:italic> maturation (IVM) has been applied is polycystic ovarian syndrome. In a concise review we present the techniques used for the IVM of oocytes and the role of hormones and growth factors in IVM and subsequent fertilization and early embryonic development.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1365.020","type":"journal-article","created":{"date-parts":[[2007,2,16]],"date-time":"2007-02-16T19:26:13Z","timestamp":1171653973000},"page":"235-246","source":"Crossref","is-referenced-by-count":27,"title":["Oocyte Maturation in Assisted Reproductive Techniques"],"prefix":"10.1111","volume":"1092","author":[{"given":"DIMITRIS","family":"LOUTRADIS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ERASMIA","family":"KIAPEKOU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EVANGELIA","family":"ZAPANTI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ARISTIDIS","family":"ANTSAKLIS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,31]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92957-4"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-199807000-00024"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.62.5.665"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(65)92903-X"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/208349a0"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/221632a0"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61101-7"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)56891-5"},{"key":"e_1_2_7_10_2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1242\/jcs.2.2.213","article-title":"The fine structure of oogonia and oocytes in human ovaries","volume":"2","author":"Baker T.G.","year":"1967","journal-title":"J. Cell Sci."},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/3.3.281"},{"key":"e_1_2_7_12_2","first-page":"587","volume-title":"Williams textbook of endocrinology","author":"Bulum S.E.","year":"2003"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1963.0055"},{"key":"e_1_2_7_14_2","first-page":"98","article-title":"The development of the mouse ovary from birth to maturity","volume":"62","author":"Peters H.","year":"1969","journal-title":"Acta. Endocrinol. (Copenh)"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-17-2-121"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod17.5.635"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0770287"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod19.5.959"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001970107"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.4.1239"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.5.5987"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.14310\/horm.2002.11153"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2795(200103)58:3<287::AID-MRD7>3.0.CO;2-G"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(98)00166-X"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4320(03)00088-5"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/4.2.103"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-200406000-00003"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod33.5.1041"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(94)90300-X"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1120180202"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(83)90087-8"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60511-1"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0045-6039(85)90570-6"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(88)90135-2"},{"key":"e_1_2_7_35_2","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1242\/dev.106.4.799","article-title":"Molecular characteristics of cytostatic factors in amphibian egg cytosols","volume":"106","author":"Shibuya E.K.","year":"1989","journal-title":"Development"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(97)00406-8"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00574-9"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.5.1032"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod54.1.197"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(97)00416-0"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.10.2519"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)54068-0"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)00398-1"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a135896"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00422-2"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)58330-7"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.7.1847"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh768"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.4.747"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.11.3132"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.1530\/rep.0.1220587"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199911183412118"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(98)00416-6"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg335"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0010230"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a138556"},{"key":"e_1_2_7_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/415385a"},{"key":"e_1_2_7_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/428137a"},{"key":"e_1_2_7_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17222-X"},{"key":"e_1_2_7_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.suppl_1.145"},{"key":"e_1_2_7_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(81)90193-7"},{"key":"e_1_2_7_62_2","doi-asserted-by":"publisher","DOI":"10.1530\/rep.0.1210455"},{"key":"e_1_2_7_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)00071-2"},{"key":"e_1_2_7_64_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod41.2.371"},{"key":"e_1_2_7_65_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-116-1-406"},{"key":"e_1_2_7_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.3.664"},{"key":"e_1_2_7_67_2","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.1010697"},{"key":"e_1_2_7_68_2","first-page":"641","article-title":"Insulin\u2010like growth factors and ovarian follicular development","volume":"13","author":"Giudice L.C.","year":"1992","journal-title":"Endocr. Rev."},{"key":"e_1_2_7_69_2","first-page":"319","volume-title":"The Ovary","author":"Adashi E.Y.","year":"1993"},{"key":"e_1_2_7_70_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod48.3.467"},{"key":"e_1_2_7_71_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.10.7.903"},{"key":"e_1_2_7_72_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod55.1.152"},{"key":"e_1_2_7_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)56033-6"},{"key":"e_1_2_7_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4320(98)00071-2"},{"key":"e_1_2_7_75_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2795(199908)53:4<398::AID-MRD5>3.0.CO;2-I"},{"key":"e_1_2_7_76_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0967199400001076"},{"key":"e_1_2_7_77_2","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.155.241"},{"key":"e_1_2_7_78_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod41.1.26"},{"key":"e_1_2_7_79_2","doi-asserted-by":"publisher","DOI":"10.1159\/000181925"},{"key":"e_1_2_7_80_2","doi-asserted-by":"publisher","DOI":"10.1159\/000016637"},{"key":"e_1_2_7_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61793-2"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1365.020","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1365.020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T21:46:13Z","timestamp":1695678373000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1365.020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":80,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1196\/annals.1365.020"],"URL":"https:\/\/doi.org\/10.1196\/annals.1365.020","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}