{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:08Z","timestamp":1761058628281},"reference-count":63,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,1,31]],"date-time":"2007-01-31T00:00:00Z","timestamp":1170201600000},"content-version":"vor","delay-in-days":61,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract:\u2002<\/jats:sc><\/jats:bold>  <jats:bold>Interferon\u2010\u03b3\u2010inducible T cell\u2010\u03b1 chemoattractant (ITAC) is a chemokine, directing activated T lymphocytes toward sites of inflammation. ADAM\u20108 (A disintegrin and metalloprotease\u20108) is a glycoprotein expressed in cells promoting inflammation. Elastase, a protease targeting at the degradation of intra\u2010 or extracellular proteins, is inhibited by secretory leukocyte proteinase inhibitor (SLPI), which protects against microbial invasion. Adhesion molecules (soluble intercellular adhesion molecule\u2014sICAM\u20101 and soluble vascular cell adhesion molecule\u2014sVCAM\u20101) serve as markers of inflammation or tissue damage. We hypothesized that elevated midtrimester amniotic fluid concentrations of above substances, and decreased levels of SLPI could possibly be useful predictors of asymptomatic intra\u2010amniotic inflammation and\/or infection, eventually resulting in preterm labor and delivery. The study involved 312 women undergoing midtrimester amniocentesis. Thirteen cases, progressing to preterm delivery (&lt;37 weeks), were matched with 21 controls (delivering &gt;37 weeks) for age, parity, and gestational age at amniocentesis. Amniotic fluid levels of the above substances were measured by enzyme\u2010linked immunosorbent assay (ELISA). Only amniotic fluid ITAC and ADAM\u20108 levels were significantly higher (<jats:italic>P<\/jats:italic>= 0.005 and <jats:italic>P<\/jats:italic> &lt; 0.02, respectively) in women delivering at &lt;37 weeks than at &gt;37 weeks. SLPI concentrations significantly increased in women going into labor without ruptured membranes irrespective of pre\u2010 or term delivery (<jats:italic>P<\/jats:italic> &lt; 0.007, <jats:italic>P<\/jats:italic> &lt; 0.001, respectively) and correlated with elastase (<jats:italic>r<\/jats:italic>= 0.508, <jats:italic>P<\/jats:italic> &lt; 0.002). In conclusion, elevated midtrimester amniotic fluid levels of ITAC and ADAM\u20108 could predict occult infections\/inflammations, possibly resulting in preterm birth.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1365.043","type":"journal-article","created":{"date-parts":[[2007,2,16]],"date-time":"2007-02-16T19:26:13Z","timestamp":1171653973000},"page":"440-449","source":"Crossref","is-referenced-by-count":33,"title":["Possible Early Prediction of Preterm Birth by Determination of Novel Proinflammatory Factors in Midtrimester Amniotic 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