{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:08:45Z","timestamp":1760954925239},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,9,6]],"date-time":"2006-09-06T00:00:00Z","timestamp":1157500800000},"content-version":"vor","delay-in-days":36,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract:\u2002<\/jats:sc><\/jats:bold>  <jats:bold>Dihydropyrimidinase\u2010related protein 2 (DRP\u20102 or DPYSL\u20102)mediates the intracellular response to collapsin, a repulsive extracellular guidance cue or axonal outgrowth. DRP\u20102 is also referred to as collapsin response mediator protein 2 (CRMP\u20102). We have previously demonstrated that the DRP\u20102 gene is associated with susceptibility to schizophrenia, but not to bipolar disorders. In addition, a genetic association was observed with paranoid\u2010type schizophrenia, but not with hebephrenic\u2010type schizophrenia. It has been well documented that repeated abuse of methamphetamine (METH) for a long period frequently produces psychotic symptoms, such as auditory hallucinations and delusions that are hardly distinguishable from those of paranoid\u2010type schizophrenia. Therefore, we hypothesized that a certain genetic variant of the DRP\u20102 gene may affect individual vulnerability to the development of METH\u2010induced psychosis. We examined the genetic association by a case\u2013control method. The polymorphism *2236T&gt;C in the 3\u2032 untranslated region of the DRP\u20102 gene, which has been shown to be a negative genetic risk factor for paranoid\u2010type schizophrenia, was analyzed in 198 patients with METH psychosis and 221 corresponding healthy controls in a Japanese population. No significant association of the DRP\u20102 gene with METH psychosis was found. Neither did we find an association with the clinical phenotype of METH psychosis, such as the age of first consumption of METH, latency to development of psychosis after METH abuse, prognosis of psychosis after detoxification from METH use, complication of spontaneous relapse of psychosis without reconsumption of the drug, or multisubstance abuse status. These findings indicate that a genetic variant of the DRP\u20102 gene may not affect the risk of METH psychosis or any clinical phenotype of the disorder.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1369.008","type":"journal-article","created":{"date-parts":[[2006,11,15]],"date-time":"2006-11-15T21:45:57Z","timestamp":1163627157000},"page":"90-96","source":"Crossref","is-referenced-by-count":15,"title":["Association Study of the Dihydropyrimidinase\u2010Related Protein 2 Gene and Methamphetamine Psychosis"],"prefix":"10.1111","volume":"1074","author":[{"given":"H.","family":"UJIKE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"SAKAI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"NAKATA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"TANAKA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"KODAKA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"OKAHISA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"HARANO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"INADA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"YAMADA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"KOMIYAMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"HORI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"SEKINE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"IWATA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"SORA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"IYO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"OZAKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"KURODA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(96)00445-3"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-02-00688.1996"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/376509a0"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-10-06757.1995"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/90476"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.11.012"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000696"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01729-8"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00824-3"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30181"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1316.035"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-002-0024-7"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500189"},{"key":"e_1_2_6_15_2","first-page":"1","article-title":"Positive association of AKT1 haplotype to Japanese methamphetamine use disorder","volume":"28","author":"Ikeda M.","year":"2005","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.07.023"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001029"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FMJ04003X4"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1369.008","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1369.008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T23:34:30Z","timestamp":1695684870000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1369.008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1196\/annals.1369.008"],"URL":"https:\/\/doi.org\/10.1196\/annals.1369.008","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}