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Interestingly, the rewarding effects of cocaine are retained in dopamine transporter (DAT) knockout (KO) mice, while serotonin transporter (SERT) and DAT double KO mice do not exhibit conditioned place preference (CPP) to cocaine. These data suggest that SERT inhibition decreases the rewarding effects of psychostimulants. To further test this hypothesis, in the present study, we investigated the effects of intraperitoneal (i.p.) injections of 20 mg\/kg fluoxetine, a selective serotonin reuptake inhibitor (SSRI), on 2 mg\/kg METH (i.p.) CPP and locomotor sensitization to 1 mg\/kg METH (i.p.) in C57BL\/6J mice. Fluoxetine treatment before both the conditioning and preference tests abolished METH CPP. A two\u2010way analysis of variance (ANOVA) revealed that METH CPP tended to be lower in mice pretreated with fluoxetine before the preference test than in control mice pretreated with saline before the preference test. Furthermore, pretreatment with fluoxetine had inhibitory effects on METH\u2010induced locomotor sensitization. These results suggest that fluoxetine, a widely used medication for depression, may be also a useful tool for treating METH dependence.<\/jats:bold><\/jats:p>","DOI":"10.1196\/annals.1369.026","type":"journal-article","created":{"date-parts":[[2006,11,15]],"date-time":"2006-11-15T21:45:57Z","timestamp":1163627157000},"page":"295-302","source":"Crossref","is-referenced-by-count":32,"title":["Fluoxetine as a Potential Pharmacotherapy for Methamphetamine Dependence"],"prefix":"10.1111","volume":"1074","author":[{"given":"YUKIO","family":"TAKAMATSU","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIDEKO","family":"YAMAMOTO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YASUKAZU","family":"OGAI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YOKO","family":"HAGINO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ATHINA","family":"MARKOU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAZUTAKA","family":"IKEDA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","DOI":"10.18356\/3a901542-en","volume-title":"World Drug Report 2005","author":"United Nations Office for Drug Control and Crime Prevention","year":"2005"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-002-0024-7"},{"key":"e_1_2_6_4_2","volume-title":"Research Report Series: Methamphetamine Abuse and Addiction","author":"National Institute on Drug Abuse (NIDA)","year":"2002"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.13.7699"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/381"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.091039298"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300476"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(89)90296-7"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300463"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.09.026"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-05-04102.1995"},{"key":"e_1_2_6_13_2","first-page":"257","article-title":"Long\u2010term effects of multiple doses of methamphetamine on tryptophan hydroxylase and tyrosine hydroxylase activity in rat brain","volume":"214","author":"Hotchkiss A.J.","year":"1980","journal-title":"J. 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