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We analyzed trends in 56 different cancer sites and subsites in the U.S. SEER registries in the period 1975\u20132002 using joinpoint analysis. The increase in cancer incidence for all sites combined that became evident with the inception of the SEER registries in the mid\u20101970s has abated since the early 1990s. Among the 15 most common cancer sites in men, sites with increasing incidence rates during the most recent time period include melanoma of the skin and cancers of the prostate, kidney and renal pelvis (kidney), and esophagus. Among women, incidence rates are increasing for leukemia, non\u2010Hodgkin's lymphoma, melanoma, and cancers of the breast, thyroid, urinary bladder, and kidney. Incidence rates for all childhood cancers combined increased 0.6% per year from 1975 to 2002. Cancer mortality rates have decreased in the United States since 1991 in both men and in women; site\u2010specific death rates have decreased in the most recent time period for 12 of the top 15 cancer sites in men and 9 of the top 15 cancer sites in women. Similar trends in cancer incidence and mortality have been reported in other industrialized countries. Possible reasons for these trends are discussed.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1371.048","type":"journal-article","created":{"date-parts":[[2006,11,22]],"date-time":"2006-11-22T03:36:57Z","timestamp":1164166617000},"page":"29-53","source":"Crossref","is-referenced-by-count":58,"title":["Interpreting Cancer Trends"],"prefix":"10.1111","volume":"1076","author":[{"given":"ELIZABETH M.","family":"WARD","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MICHAEL J.","family":"THUN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LINDSAY M.","family":"HANNAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AHMEDIN","family":"JEMAL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,5]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji289"},{"key":"e_1_2_5_3_2","unstructured":"Surveillance Research Program National Cancer Institute SEER*Stat software (http:\/\/www.seer.cancer.gov\/seerstat) version 6.1.4."},{"key":"e_1_2_5_4_2","unstructured":"Surveillance Epidemiology and End Results (SEER) Program(http:\/\/www.seer.cancer.gov) SEER*Stat Database: Incidence \u2010 SEER 9 Regs Public\u2010Use Nov 2004 Sub (1973\u20102002) National Cancer Institute DCCPS Surveillance Research Program Cancer Statistics Branch released April 2005 based on the November 2004 submission."},{"key":"e_1_2_5_5_2","volume-title":"SEER Cancer Statistics Review, 1975\u20102002","author":"Ries L.A.G.","year":"2005"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910170209"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/88.21.1571"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.43.1.27"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.53.6.342"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7784"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520310046028"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010090"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1158\/1055-9965.340.13.3","article-title":"The role of tomato products and lycopene in the prevention of prostate cancer: a meta\u2010analysis of observational studies","volume":"13","author":"Etminan M.","year":"2004","journal-title":"Cancer Epidemiol. 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