{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:17:50Z","timestamp":1787505470644,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T00:00:00Z","timestamp":1164672000000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:sc>Abstract:\u2002<\/jats:sc>\n                    <\/jats:bold>\n                    <jats:bold>\n                      This study investigated the effect of streptozotocin (STZ)\u2010induced type 1 diabetes mellitus (DM) on total protein concentration and levels of sodium (Na\n                      <jats:sup>+<\/jats:sup>\n                      ), potassium (K\n                      <jats:sup>+<\/jats:sup>\n                      ), magnesium (Mg\n                      <jats:sup>2+<\/jats:sup>\n                      ), zinc (Zn\n                      <jats:sup>2+<\/jats:sup>\n                      ), copper (Cu\n                      <jats:sup>2+<\/jats:sup>\n                      ), calcium (Ca\n                      <jats:sup>2+<\/jats:sup>\n                      ), and iron (Fe\n                      <jats:sup>2+<\/jats:sup>\n                      ) in the pancreas, parotid, submandibular, and lacrimal glands of the rat, compared to age\u2010matched control animals. Protein concentrations were measured by the Bradford Assay, whereas levels of Na\n                      <jats:sup>+<\/jats:sup>\n                      , K\n                      <jats:sup>+<\/jats:sup>\n                      , Mg\n                      <jats:sup>2+<\/jats:sup>\n                      , Zn\n                      <jats:sup>2+<\/jats:sup>\n                      , Cu\n                      <jats:sup>2+<\/jats:sup>\n                      , Ca\n                      <jats:sup>2+<\/jats:sup>\n                      , and Fe\n                      <jats:sup>2+<\/jats:sup>\n                      were measured by flame photometry and atomic absorbance spectrophotometry. The results show marked changes in the characteristics of diabetic and control animals. Diabetic rats and their different glands weighed significantly (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05) less compared to age\u2010matched controls. Diabetic rats also have significantly elevated blood glucose and significantly reduced plasma insulin, compared to controls. The results also show that the concentrations of proteins and levels of cations were significantly (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05) reduced in the pancreas, parotid, submandibular and lacrimal glands of diabetic rats, compared to glands from age\u2010matched animals. These differences in the cation contents and protein levels in STZ\u2010induced DM in this study, along with supporting evidences from previous studies, may provide evidence for the development of long\u2010term complications of DM including exocrine gland deficiencies.\n                    <\/jats:bold>\n                  <\/jats:p>","DOI":"10.1196\/annals.1372.019","type":"journal-article","created":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T15:08:44Z","timestamp":1165417724000},"page":"503-519","source":"Crossref","is-referenced-by-count":23,"title":["Effects of Streptozotocin\u2010Induced Type 1 Diabetes Mellitus on Total Protein Concentrations and Cation Contents in the Isolated Pancreas, Parotid, Submandibular, and Lacrimal Glands of Rats"],"prefix":"10.1111","volume":"1084","author":[{"given":"NAVIN R.","family":"CHANGRANI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"APURVA","family":"CHONKAR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ERNEST","family":"ADEGHATE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JAIPAUL","family":"SINGH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,28]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00589222"},{"key":"e_1_2_5_3_2","first-page":"1069","volume-title":"WB Saunders","author":"Kumar P.","year":"2002"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/414782a"},{"key":"e_1_2_5_5_2","first-page":"14","volume-title":"Handbook of Diabetes","author":"Williams J.C.","year":"1998"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4805-8_13"},{"key":"e_1_2_5_7_2","first-page":"136","volume-title":"Applications Manual to Accompany Fundamentals of Anatomy & Physiology","author":"Martini F.H.","year":"2004"},{"key":"e_1_2_5_8_2","first-page":"40","volume-title":"Structures and functions of the pancreas. In An Illustrated Review of Anatomy & Physiology","author":"Bastian J.F.","year":"1994"},{"key":"e_1_2_5_9_2","first-page":"575","volume-title":"Digestive system. In Vander's Human Physiology\u2014The Mechanisms of Body Function","author":"Widmaier E.P.","year":"2006"},{"key":"e_1_2_5_10_2","first-page":"531","volume-title":"A detailed review of digestive system. In Principles of Anatomy & Physiology","author":"Tortora G.J.","year":"2003"},{"key":"e_1_2_5_11_2","first-page":"35","article-title":"Exocrine pancreatic insufficiency in diabetes mellitus","volume":"12","author":"Singh J.","year":"2004","journal-title":"Int. J. Diabetes Metab"},{"key":"e_1_2_5_12_2","first-page":"632","volume-title":"Physiology, 4th ed","author":"Berne R.M.","year":"1998"},{"key":"e_1_2_5_13_2","first-page":"G563","article-title":"Adrenergic nervous control of cAMP\u2010mediated amylase secretion in the rat pancreas","volume":"246","author":"Pearson G.T.","year":"1984","journal-title":"Am. J. Physiol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:MCBI.0000028744.13307.73"},{"key":"e_1_2_5_15_2","unstructured":"Patel R.2005.Cellular mechanism of exocrine pancreatic insufficiency in diabetes mellitus.PhD thesis University of Central Lancashire."},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114742"},{"key":"e_1_2_5_18_2","first-page":"15P","article-title":"Effects of ageing on morphology and \u03b1\u2010amylase release in the isolated rat parotid gland","volume":"543","author":"Mahay S.","year":"2002","journal-title":"J. Physiol"},{"key":"e_1_2_5_19_2","unstructured":"Mahay S.K.2005.The effects of aging and streptozotocin (STZ)\u2013induced diabetes mellitus on the rodent parotid gland.PhD thesis University of Central Lancashire."},{"key":"e_1_2_5_20_2","first-page":"31","article-title":"Effect of secretion on vagal stimulation\u2010evoked exocrine pancreatic secretion in the rat","volume":"49","author":"Wisdom D.","year":"1993","journal-title":"Rev. Esp. Fisiol"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2350125"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00226780"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1998.10718735"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02784616"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4680(02)00033-0"},{"key":"e_1_2_5_26_2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0002-9394(66)91676-X","article-title":"The lacrimal system and its treatment","volume":"62","author":"Jones L.T.","year":"1966","journal-title":"Am. J. Ophthalmol"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2001.10719034"},{"key":"e_1_2_5_28_2","first-page":"161","article-title":"Effect of extracellular magnesium on secretagogue\u2010evoked amylase secretion in the isolated rat parotid gland segments","volume":"15","author":"Mata A.D.","year":"2002","journal-title":"Mag. Res"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1992.sp019028"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/319600a0"},{"key":"e_1_2_5_31_2","first-page":"41","article-title":"Zinc, copper and magnesium status in insulin\u2010dependent diabetes","volume":"26","author":"Isbir T.","year":"1994","journal-title":"Diabetes Res"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)91400-4"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-180-42182"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1372.019","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1372.019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T23:39:40Z","timestamp":1695598780000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1372.019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1196\/annals.1372.019"],"URL":"https:\/\/doi.org\/10.1196\/annals.1372.019","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11]]}}}