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However, it is now becoming evident that when radicals are measured within cells, melatonin increases, rather than decreasing, radical production. Herein we demonstrate a pro\u2010oxidant effect of melatonin in U937 cells by showing an increase of intracellular oxidative species and a depletion of glutathione (GSH). The activity of glutathione peroxidase is not modified by melatonin treatment as it does occur in other experimental models.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1378.050","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T18:27:35Z","timestamp":1173205655000},"page":"10-16","source":"Crossref","is-referenced-by-count":32,"title":["Intracellular Pro\u2010oxidant Activity of Melatonin Deprives U937 Cells of Reduced Glutathione without Affecting Glutathione Peroxidase Activity"],"prefix":"10.1111","volume":"1091","author":[{"given":"MARIA CRISTINA","family":"ALBERTINI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FLAVIA","family":"RADOGNA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AUGUSTO","family":"ACCORSI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FRANCESCO","family":"UGUCCIONI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LAURA","family":"PATERNOSTER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CLAUDIA","family":"CERELLA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MILENA","family":"DE NICOLA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIA","family":"D'ALESSIO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANTONIO","family":"BERGAMASCHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDREA","family":"MAGRINI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LINA","family":"GHIBELLI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,26]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1998.tb00544.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1998.tb00359.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(98)00052-5"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(98)00180-4"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-079X.2003.00092.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4165(02)00527-5"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-079X.2003.02112.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)02530-7"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.11.14.9409550"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-20-08236.1998"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9370"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/1043-2760(95)00192-1"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(96)00046-9"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00918-6"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)00435-4"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(00)00572-5"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(98)80147-6"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(99)00242-7"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01669-0"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.154.7.3194"},{"key":"e_1_2_5_22_2","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.4049\/jimmunol.157.6.2395","article-title":"Role of reactive oxygen intermediates in TCR\u2010induced death of T cell blasts and hybridomas","volume":"157","author":"Williams M.S.","year":"1996","journal-title":"J. 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