{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T20:52:40Z","timestamp":1793220760461,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,8,28]],"date-time":"2007-08-28T00:00:00Z","timestamp":1188259200000},"content-version":"vor","delay-in-days":88,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract<\/jats:sc>:\u2002<\/jats:bold>  <jats:bold>Inflammatory myopathies (IM) are chronic disorders characterized by muscular accumulation of inflammatory cells that promote cytotoxicity and tissue damage. Overexpression of chemokines and cytokines as well as imbalance of dendritic cells (DC) homeostasis have been postulated to exert a role in both dermatomyositis (DM) and polymyositis (PM). We studied the T helper (Th)\u20101 and Th2 cytokine levels by enzyme linked immunosorbent assay (ELISA) and the muscular expression of IL\u201018 and its receptor by both histochemistry (HIC) and <jats:italic>in situ<\/jats:italic> hybridization (ISH) in both patients and normal controls. Also, the cell populations infiltrating the muscles were investigated. We present evidence that DM and PM are characterized by a predominant Th1 immune response with high production of both interferon (IFN)\u2010\u03b3 and interleukin (IL)\u201018 in the presence of reduced levels of IL\u20104 and IL\u20106. IL\u201018 was also demonstrated in muscles and produced by both macrophages and DC surrounding either perivascular and perimysium areas or endomysium. IL\u201018R was highly expressed by T cells and DC as well as by endothelial cells (EC) and smooth muscle cells (SMC). High concentrations of serum and muscular IL\u201018 suggest that deregulated IL\u201018\/IL\u201018R pathway may be pathogenetic in IM and measurement of IL\u201018 might be predictive of the disease activity.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1381.020","type":"journal-article","created":{"date-parts":[[2007,9,5]],"date-time":"2007-09-05T15:32:48Z","timestamp":1189006368000},"page":"184-192","source":"Crossref","is-referenced-by-count":27,"title":["Increased IL\u201018 Production by Dendritic Cells in Active Inflammatory Myopathies"],"prefix":"10.1111","volume":"1107","author":[{"given":"MARCO","family":"TUCCI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"COSIMA","family":"QUATRARO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FRANCO","family":"DAMMACCO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FRANCO","family":"SILVESTRIS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,8,28]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14368-1"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199711000-00007"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.12.1779"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.11428"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03180.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200104)44:4<856::AID-ANR142>3.0.CO;2-A"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(02)00755-3"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.4.1862"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2322"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.10.6987"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400514"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0602313"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2000.00836.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02588.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2005.04.009"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/12.9.1329"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.3.1087"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000234111.31239.c3"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20266"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1361.084"},{"issue":"1","key":"e_1_2_5_22_2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1042\/BJ20040741","article-title":"CD83 is performed inside monocytes, macrophages and dendritic cells, but it is only stably expressed on activated dendritic cells","volume":"385","author":"Cao W.","year":"2005","journal-title":"Biochem. 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