{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:57:34Z","timestamp":1791122254950,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,8,28]],"date-time":"2007-08-28T00:00:00Z","timestamp":1188259200000},"content-version":"vor","delay-in-days":88,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract:\u2002<\/jats:sc><\/jats:bold>  <jats:bold>It still remains unclear how antimitochondrial autoantibodies (AMA) are involved with immunopathogenesis of primary biliary cirrhosis (PBC). We have suggested the potential role of IgA\u2010AMA in damage to epithelial cells in PBC. In the current study, we investigated whether IgA\u2010AMA were detectable in sera and saliva of PBC patients, to examine the association between detectable IgA\u2010type autoantibodies in sera or saliva and progression of liver diseases. Fifty\u2010three patients with PBC were enrolled, and IgA\u2010AMA in sera and saliva were sought by immunoblotting using pork heart mitochondria as antigens. The progression of PBC was determined as Scheuer's classification consisting of four histological stages. We found IgA\u2010AMA, IgA\u2010anti\u2010PDC\u2010E2, and IgA\u2010anti\u2010E3BP in 43\/53 (81%), 37\/53 (70%), and 35\/53 (66%) sera of patients with PBC, but none of controls. The progression of PBC was statistically associated with presence of IgA\u2010anti\u2010PDC\u2010E2 (<jats:italic>P<\/jats:italic>= 0.0124), but neither with IgA\u2010AMA (<jats:italic>P<\/jats:italic>= 0.1296) nor anti\u2010IgA\u2010E3BP (<jats:italic>P<\/jats:italic>= 0.5973). In saliva, detectable IgA\u2010AMA, IgA\u2010anti\u2010PDC\u2010E2, and IgA\u2010anti\u2010E3BP were noted in 12\/26 (46%), 6\/26 (23%), and 11\/26 (42%), respectively. Detection of IgA\u2010anti\u2010PDC\u2010E2 was strongly associated with progression of PBC (<jats:italic>P<\/jats:italic>= 0.0002), whereas detection of IgA\u2010AMA and IgA\u2010anti\u2010E3BP were not associated (<jats:italic>P<\/jats:italic>= 0.2145 and <jats:italic>P<\/jats:italic>= 0.5118). The current findings suggest that the presence of IgA\u2010anti\u2010PDC\u2010E2 in sera or saliva might be associated with progression of PBC, although a prospective study with PBC patients with detectable IgA\u2010anti\u2010PDC\u2010E2 at early stages will be required to conclude the contribution of IgA\u2010anti\u2010PDC\u2010E2 to the progression of PBC.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1381.028","type":"journal-article","created":{"date-parts":[[2007,9,5]],"date-time":"2007-09-05T15:32:48Z","timestamp":1189006368000},"page":"259-270","source":"Crossref","is-referenced-by-count":28,"title":["The Clinical Significance of IgA Antimitochondrial Antibodies in Sera and Saliva in Primary Biliary Cirrhosis"],"prefix":"10.1111","volume":"1107","author":[{"given":"ATSUSHI","family":"TANAKA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SAEKO","family":"NEZU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SATOKO","family":"UEGAKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MASAKI","family":"MIKAMI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SHUHEI","family":"OKUYAMA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NAOHIRO","family":"KAWAMURA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MITSUHIKO","family":"AISO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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