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In the present study, specimens from the sigmoid colon of ulcerative colitis (UC) and non\u2010UC patients were examined for immunohistochemistry and <jats:italic>in vitro<\/jats:italic> receptor autoradiography. Marked occurrence of VIP binding was observed in the mucosa. However, there were very low levels of binding in areas showing pronounced inflammation\/derangement. The study shows that marked derangement of the mucosa leads to a distinct decrease in VIP binding. Thus, it is possible that a decrease in trophic and anti\u2010inflammatory VIP effects occurs in areas exhibiting a very marked inflammation<\/jats:bold>.<\/jats:p>","DOI":"10.1196\/annals.1381.030","type":"journal-article","created":{"date-parts":[[2007,9,5]],"date-time":"2007-09-05T15:32:48Z","timestamp":1189006368000},"page":"280-289","source":"Crossref","is-referenced-by-count":10,"title":["Decrease in Binding for the Neuropeptide VIP in Response to Marked Inflammation of the Mucosa in Ulcerative Colitis"],"prefix":"10.1111","volume":"1107","author":[{"given":"MARIA","family":"J\u00d6NSSON","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6RJAN","family":"NORRG\u00c5RD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MAGNUS","family":"HANSSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STURE","family":"FORSGREN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-3150.2004.00487.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(94)90070-1"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-10-03622.2000"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2001.00703.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2004.12.018"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(96)70034-3"},{"key":"e_1_2_6_8_2","first-page":"400","article-title":"Peptidergic nerves in the colon of patients with ulcerative colitis","volume":"47","author":"Tomita R.","year":"2000","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990505)81:3<376::AID-IJC11>3.0.CO;2-5"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026627106310"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02087921"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb11194.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(89)90154-X"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002100100454"},{"key":"e_1_2_6_15_2","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0889-8553(21)00568-9","article-title":"Neuroimmunomodulation in the intestinal mucosa","volume":"20","author":"Ottaway C.A.","year":"1991","journal-title":"Gastroenterol. 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