{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T05:04:45Z","timestamp":1785647085089,"version":"3.56.0"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,5]],"date-time":"2006-12-05T00:00:00Z","timestamp":1165276800000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract:\u2002<\/jats:sc><\/jats:bold>  <jats:bold>The major disease processes affecting the aorta are aortic aneurysms and dissections. Aneurysms are usually described in terms of their anatomic location, with thoracic aortic aneurysms (TAAs) involving the ascending and descending aorta in the thoracic cavity and abdominal aortic aneurysms (AAAs) involving the infrarenal abdominal aorta. Both thoracic and abdominal aortas are elastic arteries, and share similarities in their physical structures and cellular components. However, thoracic and abdominal aortas differ in their biochemical properties and the origin of their vascular smooth muscle cells (VSMCs). These similarities and differences between thoracic and abdominal aortas provide the basis for the various pathologic mechanisms observed in this disease. This review focuses on the comparison of the pathologic mechanisms involved in TAA and AAA.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1383.013","type":"journal-article","created":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T19:58:12Z","timestamp":1166644692000},"page":"339-352","source":"Crossref","is-referenced-by-count":241,"title":["Pathogenesis of Thoracic and Abdominal Aortic Aneurysms"],"prefix":"10.1111","volume":"1085","author":[{"given":"DONG\u2010CHUAN","family":"GUO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTINA L.","family":"PAPKE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RUMIN","family":"HE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DIANNA M.","family":"MILEWICZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,5]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"1199","article-title":"Human abdominal aortic aneurysms. Immunophenotypic analysis suggesting an immune\u2010mediated response","volume":"137","author":"Koch A.E.","year":"1990","journal-title":"Am. J. Pathol"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000012662.29622.00"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2001.1368"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/362801a0"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.13.5134"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.12.5252"},{"key":"e_1_2_4_8_2","first-page":"367","article-title":"Apoptosis is abundant in human atherosclerotic lesions, especially in inflammatory cells (macrophages and T cells), and may contribute to the accumulation of gruel and plaque instability","volume":"149","author":"Bjorkerud S.","year":"1996","journal-title":"Am. J. Pathol"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199612)180:4<423::AID-PATH677>3.0.CO;2-1"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(94)05463-S"},{"key":"e_1_2_4_11_2","first-page":"251","article-title":"Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin\u20101 beta\u2010converting enzyme","volume":"147","author":"Geng Y.J.","year":"1995","journal-title":"Am. J. Pathol"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(98)00212-0"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2003.10.047"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.11.1055"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019501-199710000-00005"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1067\/msg.2002.121421"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.1.96"},{"key":"e_1_2_4_18_2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/00015458.1998.12098413","article-title":"Pathogenesis of abdominal aortic aneurysm (AAA) formation","volume":"98","author":"Limet R.","year":"1998","journal-title":"Acta. Chir. Belg"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb33305.x"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(95)70110-9"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(97)70222-2"},{"key":"e_1_2_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(87)90003-7"},{"key":"e_1_2_4_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc37t1.094596"},{"key":"e_1_2_4_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/hq0901.097004"},{"key":"e_1_2_4_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb33307.x"},{"key":"e_1_2_4_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215334"},{"key":"e_1_2_4_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.526152"},{"key":"e_1_2_4_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.7.1589"},{"key":"e_1_2_4_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.82.2.221"},{"key":"e_1_2_4_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.511717"},{"key":"e_1_2_4_31_2","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.27107"},{"key":"e_1_2_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.09.018"},{"key":"e_1_2_4_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1721"},{"key":"e_1_2_4_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000127857.77161.A1"},{"key":"e_1_2_4_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.20.2461"},{"key":"e_1_2_4_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000078634.33124.95"},{"key":"e_1_2_4_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.20.2469"},{"key":"e_1_2_4_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01323"},{"key":"e_1_2_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64206-X"},{"key":"e_1_2_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(00)00196-0"},{"key":"e_1_2_4_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.11.6.1667"},{"key":"e_1_2_4_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000214999.12921.4f"},{"key":"e_1_2_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2005.04.020"},{"key":"e_1_2_4_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb03976.x"},{"key":"e_1_2_4_45_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.0177"},{"key":"e_1_2_4_46_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2002.1912"},{"key":"e_1_2_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(97)00138-X"},{"key":"e_1_2_4_48_2","first-page":"125","article-title":"Abdominal aortic aneurysms (AAA) is a specific antigen\u2010driven T\u2010cell","author":"Platsoucas C.D.","year":"2006","journal-title":"Disease"},{"key":"e_1_2_4_49_2","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1096\/fj.05-3671fje","article-title":"Transmural inflammation by interferon\u2010gamma\u2010producing T cells correlates with outward vascular remodeling and intimal expansion of ascending thoracic aortic aneurysms","volume":"19","author":"Tang P.C.","year":"2005","journal-title":"FASEB J"},{"key":"e_1_2_4_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a017997"},{"key":"e_1_2_4_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb33294.x"},{"key":"e_1_2_4_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0967-2109(97)00018-5"},{"key":"e_1_2_4_53_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.18.10.1625"},{"key":"e_1_2_4_54_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1721"},{"key":"e_1_2_4_55_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7709"},{"key":"e_1_2_4_56_2","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/S0022-5223(94)70054-0","article-title":"The natural history of thoracic aortic aneurysms","volume":"107","author":"Dapunt O.E.","year":"1994","journal-title":"J. Thorac. Cardiovasc. Surg"},{"key":"e_1_2_4_57_2","first-page":"1103","article-title":"Thoracic aortic aneurysms: a population\u2010based study","volume":"92","author":"Bickerstaff L.K.","year":"1982","journal-title":"Surgery"},{"key":"e_1_2_4_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02275142"},{"issue":"1","key":"e_1_2_4_59_2","first-page":"II329","article-title":"Abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm","volume":"108","author":"Nataatmadja M.","year":"2003","journal-title":"Circulation"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1383.013","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1383.013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T13:32:31Z","timestamp":1695648751000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1383.013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1196\/annals.1383.013"],"URL":"https:\/\/doi.org\/10.1196\/annals.1383.013","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11]]}}}