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Traditional periodontal diagnostic methods include assessment of clinical parameters and radiographs. Though efficient, these conventional techniques are inherently limited in that only a historical perspective, not current appraisal, of disease status can be determined. Advances in the use of oral fluids as possible biological samples for objective measures of current disease state, treatment monitoring, and prognostic indicators have boosted saliva and other oral\u2010based fluids to the forefront of technology. Oral fluids contain locally and systemically derived mediators of periodontal disease, including microbial, host\u2010response, and bone\u2010specific resorptive markers. Although most biomarkers in oral fluids represent inflammatory mediators, several specific collagen degradation and bone turnover\u2010related molecules have emerged as possible measures of periodontal disease activity. Pyridinoline cross\u2010linked carboxyterminal telopeptide (ICTP), for example, has been highly correlated with clinical features of the disease and decreases in response to intervention therapies, and has been shown to possess predictive properties for possible future disease activity. One foreseeable benefit of an oral fluid\u2013based periodontal diagnostic would be identification of highly susceptible individuals prior to overt disease. Timely detection and diagnosis of disease may significantly affect the clinical management of periodontal patients by offering earlier, less invasive, and more cost\u2010effective treatment therapies.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1384.028","type":"journal-article","created":{"date-parts":[[2007,4,13]],"date-time":"2007-04-13T20:23:40Z","timestamp":1176495820000},"page":"230-251","source":"Crossref","is-referenced-by-count":163,"title":["Oral Fluid\u2013Based Biomarkers of Alveolar Bone Loss in Periodontitis"],"prefix":"10.1111","volume":"1098","author":[{"given":"JANET S.","family":"KINNEY","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTOPH A.","family":"RAMSEIER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WILLIAM V.","family":"GIANNOBILE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,2]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.4s.322"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.4s.338"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00189.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.821"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1990.tb02346.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1986.tb02235.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb01305.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.290103.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.1.13"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280102.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.879"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02419.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.30.2.427-433.1992"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00188.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1976.47.3.139"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2003.8.1.182"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.37"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0906-6713.2002.003422.x"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1995.tb00038.x"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1983.tb01274.x"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.4s.373"},{"key":"e_1_2_7_24_2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1600-051X.1991.tb01700.x","article-title":"Clinical risk indicators for periodontal attachment loss","volume":"18","author":"Haffajee A.D.","journal-title":"J. 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