{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T19:05:16Z","timestamp":1771527916981,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,4,13]],"date-time":"2007-04-13T00:00:00Z","timestamp":1176422400000},"content-version":"vor","delay-in-days":43,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract:\u2002<\/jats:sc><\/jats:bold>  <jats:bold>Clinical trials suggest females experience less heart failure (HF) progression, mortality, and arrhythmia frequency. HF increases Na\/Ca exchanger (NCX) expression and activity contributing to both depressed contractility and ventricular arrhythmias, but whether gender modifies this effect is unknown. Left ventricular myocytes were isolated from control and from tachycardic pacing\u2010induced failing swine hearts of both sexes. The Ni\u2010sensitive NCX current (I<jats:sub>NCX<\/jats:sub>) was measured in voltage clamp after blocking other channels. In control myocytes there is no difference in basal I<jats:sub>NCX<\/jats:sub> and \u03b2\u2010adrenergic responsiveness between male and female animals. HF greatly increased I<jats:sub>NCX<\/jats:sub> and reduced \u03b2\u2010adrenergic responsiveness in males compared to females, an effect that was eliminated by PP1. Diuretic therapy (furosemide, 1 mg\/kg\/day) further enhanced I<jats:sub>NCX<\/jats:sub> and reduced \u03b2\u2010adrenergic responsiveness in females and eliminated the gender difference. Gender\u2010specific differences in calcium handling may contribute to improved survival of females in HF.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1387.026","type":"journal-article","created":{"date-parts":[[2007,4,19]],"date-time":"2007-04-19T20:24:00Z","timestamp":1177014240000},"page":"183-189","source":"Crossref","is-referenced-by-count":24,"title":["Gender Differences in Na\/Ca Exchanger Current and \u03b2\u2010Adrenergic Responsiveness in Heart Failure in Pig Myocytes"],"prefix":"10.1111","volume":"1099","author":[{"given":"SHAO\u2010KUI","family":"WEI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHN M.","family":"MCCURLEY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEPHEN U.","family":"HANLON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARK C. 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