{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:12:23Z","timestamp":1780603943888,"version":"3.54.1"},"reference-count":73,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,7,16]],"date-time":"2007-07-16T00:00:00Z","timestamp":1184544000000},"content-version":"vor","delay-in-days":45,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract:\u2002<\/jats:sc><\/jats:bold>  <jats:bold>Mast cells are important elements of the body response to foreign antigens, being those represented either by small molecules (allergic response) or harbored by foreign microorganisms (response to parasite infection). These cells derive from hematopoietic stem\/progenitor cells present in the marrow. However, in contrast with most of the other hematopoietic lineages, mast cells do not differentiate in the marrow but in highly vascularized extramedullary sites, such as the skin or the gut. Mast cell differentiation in the marrow is activated as part of the body response to parasites. We will review here the mast cell differentiation pathway and what is known of its major intrinsic and extrinsic control mechanisms. It will also be described that thrombopoietin, the ligand for the Mpl receptor, in addition to its pivotal rule in the control of thrombocytopoiesis and of hematopoietic stem\/progenitor cell proliferation, exerts a regulatory function in mast cell differentiation. Some of the possible implications of this newly described biological activity of thrombopoietin will be discussed.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1392.024","type":"journal-article","created":{"date-parts":[[2007,7,19]],"date-time":"2007-07-19T19:28:24Z","timestamp":1184873304000},"page":"152-174","source":"Crossref","is-referenced-by-count":7,"title":["Role of Thrombopoietin in Mast Cell Differentiation"],"prefix":"10.1111","volume":"1106","author":[{"given":"ANNA RITA","family":"MIGLIACCIO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROSA ALBA","family":"RANA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALESSANDRO M.","family":"VANNUCCHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FRANCESCO A.","family":"MANZOLI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,7,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.1.F1"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1158"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/291159a0"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.7.2333.419k30_2333_2342"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5250.818"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.8.3230"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504197102"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0505073102"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0756"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1060"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3146"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1182\/blood.V81.10.2572.2572","article-title":"Infection of Nippostrongylus brasiliensis induces development of mucosal\u2010type but not connective tissue\u2010type mast cells in genetically mast cell\u2010deficient Ws\/Ws rats","volume":"81","author":"Arizono N.","year":"1993","journal-title":"Blood"},{"key":"e_1_2_6_14_2","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.4049\/jimmunol.136.4.1378","article-title":"Formation of mast cell colonies in methylcellulose by mouse peritoneal cells and differentiation of these cloned cells in both the skin and the gastric mucosa of W\/Wv mice: evidence that a common precursor can give rise to both \u201connective tissue\u2010type\u201d and \u201cmucosal\u201d mast cells","volume":"136","author":"Kobayashi T.","year":"1986","journal-title":"J. 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