{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:45:04Z","timestamp":1791107104313,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,4,18]],"date-time":"2007-04-18T00:00:00Z","timestamp":1176854400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract<\/jats:sc>:\u2002<\/jats:bold>  <jats:bold>The CC chemokine receptor 5 (CCR5) is a member of CC\u2010chemokine receptor family. CCR5 has the characteristic structure of a seven transmembrane G protein\u2013coupled receptor (GPCR), which regulates trafficking and effector functions of memory\/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands are important molecules in viral pathogenesis. CCR5 represents the co\u2010receptor for macrophage (M) and dual (T cell and M)\u2010tropic immunodeficiency viruses. Recent evidence has also demonstrated the role of CCR5 in a variety of human diseases, ranging from infectious and inflammatory diseases to cancer. In this article, we describe the involvement of CCR5 in two age\u2010related diseases, atherosclerosis and Alzheimer's disease, suggesting a possible role of chemokine system on these diseases' pathophysiology. Finally, we review the data on the probable association between CCR5\u039432 deletion and cardiovascular diseases and Alzheimer's disease.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1395.014","type":"journal-article","created":{"date-parts":[[2007,4,25]],"date-time":"2007-04-25T21:14:35Z","timestamp":1177535675000},"page":"162-172","source":"Crossref","is-referenced-by-count":49,"title":["CCR5 Receptor"],"prefix":"10.1111","volume":"1100","author":[{"given":"CARMELA RITA","family":"BALISTRERI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CALOGERO","family":"CARUSO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIA PAOLA","family":"GRIMALDI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FLORINDA","family":"LIST\u00cc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SONYA","family":"VASTO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VALENTINA","family":"ORLANDO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANNA MARIA","family":"CAMPAGNA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DOMENICO","family":"LIO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GIUSEPPINA","family":"CANDORE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1529-1049(00)00009-X"},{"key":"e_1_2_6_3_2","first-page":"S82","article-title":"Chemokines and their receptors: roles in specific clinical conditions and measurement in the clinical laboratory","volume":"123","author":"Locati M.","year":"2005","journal-title":"Am. 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