{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T01:18:41Z","timestamp":1775611121845,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,3,19]],"date-time":"2007-03-19T00:00:00Z","timestamp":1174262400000},"content-version":"vor","delay-in-days":77,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract<\/jats:sc>:\u2002<\/jats:bold><jats:bold>Etoposide, a podophylotoxin anticancer agent, induces apoptotic cell death in normal and cancer cells. Etoposide\u2010induced apoptosis plays a role in not only anticancer effect but also adverse reaction, such as myelosuppression. Since we have found that wogonin, a flavone found in<jats:italic>Scutellaria baicalensis<\/jats:italic>Georgi, prevents thymocyte apoptosis induced by various compounds including etoposide, we examined the effect of this flavone on etoposide\u2010induced apoptosis in cancer cells. Although 100 \u03bcM wogonin itself significantly increased DNA fragmentation in HL\u201060 cells, this change was not observed in Jurkat cells. On the other hand, this flavone significantly potentiated etoposide\u2010induced apoptosis in Jurkat and HL\u201060 cells. Similarly, wogonin accelerated etoposide\u2010induced cell death in lung cancer cells. Since wogonin had no effect on the action of other anticancer agents, such as 5\u2010FU and cisplatin, this flavone seems to accelerate only etoposide\u2010induced apoptotic cell death in cancer cells. These results suggest that the modification of etoposide\u2010induced apoptosis by wogonin may be available to reduce the adverse reaction of this agent.<\/jats:bold><\/jats:p>","DOI":"10.1196\/annals.1397.056","type":"journal-article","created":{"date-parts":[[2007,4,2]],"date-time":"2007-04-02T21:06:52Z","timestamp":1175548012000},"page":"521-526","source":"Crossref","is-referenced-by-count":19,"title":["Wogonin, a Plant Flavone, Potentiates Etoposide\u2010Induced Apoptosis in Cancer Cells"],"prefix":"10.1111","volume":"1095","author":[{"given":"EIBAI","family":"LEE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RIYO","family":"ENOMOTO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHIE","family":"SUZUKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MASATAKA","family":"OHNO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TOSHINORI","family":"OHASHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AZUSA","family":"MIYAUCHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ERIKO","family":"TANIMOTO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAORI","family":"MAEDA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIROYUKI","family":"HIRANO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TOSHIO","family":"YOKOI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHIYOKO","family":"SUGAHARA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,19]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"2861","article-title":"Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin","volume":"20","author":"Shieh D.E.","year":"2000","journal-title":"Anticancer Res."},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0057fje"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(01)00594-9"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.04.017"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02975846"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-002-0346-6"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(01)00876-0"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000020490.34220.6d"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)02028-6"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.1902"},{"key":"e_1_2_5_12_2","first-page":"6172","article-title":"Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6)","volume":"62","author":"Belinsky M.G.","year":"2002","journal-title":"Cancer Res."},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.30.4.457"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107041200"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.16.1295"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.17.9831"},{"key":"e_1_2_5_17_2","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0022-3565(24)39224-9","article-title":"Polymethoxylated flavones in orange juice are inhibitors of P\u2010glycoprotein but not cytochrome P450 3A4","volume":"293","author":"Takanaga H.","year":"2000","journal-title":"J. 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