{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:29:12Z","timestamp":1785151752912,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,8,29]],"date-time":"2007-08-29T00:00:00Z","timestamp":1188345600000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract<\/jats:sc>:\u2002<\/jats:bold>  <jats:bold>A novel line immunoassay for the multiparametric detection of 11 antiganglioside autoantibodies (GM1, GM2, GM3, GM4, GD1a, GD1b, GD2, GD3, GT1a, GT1b, and GQ1b) was evaluated by comparing the reactivities in sera of 77 patients with suspected or definite autoimmune peripheral neuropathies (PNP), 60 blood donors, and 30 systemic lupus erythematodes (SLE) patients. At least one antiganglioside autoantibody was detectable in 97.4% of the patients with neuropathies compared to 12.2% in the control group. A broad spectrum of reactivities with more than two antiganglioside autoantibodies including all tested gangliosides except GD2 and GT1b was found in nearly one\u2010third of the patients with neuropathies whereas in the control group autoantibody profiles with more than two reactivities were observed in two SLE patients only. For the first time anti\u2010GM4 IgG and IgM antibodies were shown in PNP including Guillain\u2013Barr\u00e9 syndrome (GBS), Miller\u2013Fisher syndrome (MFS), and multifocal motor neuropathy (MMN). Different autoantibody profiles detectable by this multiparametric assay may help to diagnose different entities within the growing spectrum of autoimmune PNP.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1398.031","type":"journal-article","created":{"date-parts":[[2007,9,4]],"date-time":"2007-09-04T05:08:39Z","timestamp":1188882519000},"page":"256-264","source":"Crossref","is-referenced-by-count":38,"title":["A New Line Immunoassay for the Multiparametric Detection of Antiganglioside Autoantibodies in Patients with Autoimmune Peripheral Neuropathies"],"prefix":"10.1111","volume":"1109","author":[{"given":"KARSTEN","family":"CONRAD","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HAUKE","family":"SCHNEIDER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TJALF","family":"ZIEMSSEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"THOMAS","family":"TALASKA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DIRK","family":"REINHOLD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RENE\u2010LOUIS","family":"HUMBEL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DIRK","family":"ROGGENBUCK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,8,29]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.6.758"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf272"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440512"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.60.8_suppl_3.S8"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67665-9"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230503"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1212\/WNL.52.3.498","article-title":"Clinicopathologic findings and prognosis of chronic inflammatory demyelinating polyneuropathy","volume":"52","author":"Buchard C.","year":"1999","journal-title":"Neurology"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000175937.31569.15"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.3.449"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf258"},{"key":"e_1_2_5_12_2","first-page":"565","article-title":"Criteria for the diagnosis of Guillain\u2013Barr\u00e9 syndrome","volume":"3","author":"Ad Hoc NINCDS Committee","year":"1978","journal-title":"Ann. 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