{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:09:27Z","timestamp":1757700567977},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,12,13]],"date-time":"2007-12-13T00:00:00Z","timestamp":1197504000000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract<\/jats:sc>:\u2002<\/jats:bold>  <jats:bold>The transforming growth factor\u2010beta (TGF\u2010\u03b2) superfamily, including TGF\u2010\u03b21 and bone morphogenetic protein (BmP2, BmP4), participates in the regulation of the developing cartilaginous otic capsule, which prefigures the endochondral bony labyrinth of the inner ear. This study investigates Smad\u20106 and \u20107, downstream components of the TGF\u2010\u03b2\/BMP signaling pathway, in otic capsule chondrogenic control, and supports a function for these inhibitory Smads as negative regulators of capsule chondrogenesis. The importance of otic capsule chondrogenic control and implications of Smad signaling for otosclerosis, a disease affecting the endochondral bony labyrinth, are indicated.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1402.005","type":"journal-article","created":{"date-parts":[[2007,12,14]],"date-time":"2007-12-14T19:53:17Z","timestamp":1197661997000},"page":"141-148","source":"Crossref","is-referenced-by-count":6,"title":["Negative Regulation of Otic Capsule Chondrogenesis"],"prefix":"10.1111","volume":"1116","author":[{"given":"WEI","family":"LIU","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SYDNEY","family":"BUTTS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HAROLD","family":"KIM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DOROTHY A.","family":"FRENZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,12,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(92)90117-Y"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1242\/dev.120.2.415","article-title":"Induction of chondrogenesis: requirement for synergistic interaction of basic fibroblast growth factor and transforming growth factor\u2010beta","volume":"120","author":"Frenz D.A.","year":"1994","journal-title":"Development"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10258"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.44.27678"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.67.1.753"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.11.3091"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20128"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(91)90476-J"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/08977199809002115"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2002.0733"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb56277.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(98)00184-1"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2002.0822"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(02)00679-8"},{"key":"e_1_2_6_16_2","first-page":"7","article-title":"Growth factor control of otic capsule chondrogenesis","volume":"18","author":"Frenz D.A.","year":"2001","journal-title":"Einstein Quart. 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