{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:35:16Z","timestamp":1785281716954,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,11,28]],"date-time":"2007-11-28T00:00:00Z","timestamp":1196208000000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract<\/jats:sc>:\u2002<\/jats:bold>  <jats:bold>The aim of this study was to evaluate the short\u2010term (1 year) changes of the lumbar spine (L2\u2013L4) bone mineral density (LS\u2010BMD) after parathyroidectomy (PTx) in pre\u2010 and postmenopausal women with primary hyperparathyroidism (PHPT). A series of 48 women (median age 56 years, range 23\u201382 years) with confirmed PHPT were prospectively enrolled in the study. Patients who received both oral contraceptives less than 2 years before the diagnosis and estrogen replacement therapy have previously been excluded. All patients underwent LS\u2010BMD by dual energy x\u2010ray absorptiometry before surgery. Patients were divided into two groups: group A (<jats:italic>n<\/jats:italic>= 12) premenopausal, and group B (<jats:italic>n<\/jats:italic>= 36) postmenopausal patients. The LS\u2010BMD was repeated 12 months after successful PTx. Basal LS\u2010BMD (0.852 \u00b1 0.061 vs. 0.748 \u00b1 0.142 g\/cm<jats:sup>2<\/jats:sup>), serum calcium (2.95 \u00b1 0.23 vs. 2.94 \u00b1 0.26 mmol\/L), creatinine (69.2 \u00b1 17.5 vs. 82.0 \u00b1 24.2 \u03bcmol\/L), alkaline phosphatase (107.4 \u00b1 43.6 vs. 151.3 \u00b1 95.7 U\/L), osteocalcin (28.6 \u00b1 9.3 vs. 28.2 \u00b1 8.3 \u03bcg\/L), and PTH (192.7 \u00b1 133.2 vs. 175.2 \u00b1 132.1 ng\/L) levels did not differ significantly (<jats:italic>P<\/jats:italic>= NS) between groups. The 1\u2010year LS\u2010BMD was 0.921 \u00b1 0.048 and 0.825 \u00b1 0.151 g\/cm<jats:sup>2<\/jats:sup> in group A and B, respectively. In group B patients, the 1\u2010year LS\u2010BMD value did not improve significantly (<jats:italic>P<\/jats:italic>= NS), while in group A patients the difference between basal and postsurgical LS\u2010BMD was significant (<jats:italic>P<\/jats:italic> &lt; 0.01). In conclusion, PTx should be considered for all patients with PHPT and loss of bone density, but in premenopausal patients a greatest improvement of BMD may be found, suggesting the need of endogenous estrogens in complete lumbar bone recovery after surgery.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1402.012","type":"journal-article","created":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T03:33:08Z","timestamp":1196479988000},"page":"357-361","source":"Crossref","is-referenced-by-count":29,"title":["Bone Mineral Density Improvement After Successful Parathyroidectomy in Pre\u2010 and Postmenopausal Women with Primary Hyperparathyroidism"],"prefix":"10.1111","volume":"1117","author":[{"given":"FRANCO","family":"LUMACHI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VALENTINA","family":"CAMOZZI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIO","family":"ERMANI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FEDERICA","family":"DE LOTTO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GIOVANNI","family":"LUISETTO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,28]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"485","volume-title":"Basic and Clinical Endocrinology","author":"Shoback D.","year":"2001"},{"key":"e_1_2_6_3_2","first-page":"1305","article-title":"PCNA\u2010LI, Ki\u201067 immunostaining, p53 activity and histopathological variables in predicting the clinical outcome in patients with parathyroid carcinoma","volume":"25","author":"Lumachi F.","year":"2006","journal-title":"Anticancer Res."},{"key":"e_1_2_6_4_2","first-page":"4803","article-title":"Parathyroid cancer: etiology, clinical presentation and treatment","volume":"26","author":"Lumachi F.","year":"2006","journal-title":"Anticancer Res."},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-003-1407-2"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-001-1142-7"},{"key":"e_1_2_6_7_2","first-page":"1","article-title":"The skeleton in primary hyperparathyroidism: a review focusing on bone remodeling, structure, mass, and fracture","volume":"102","author":"Christiansen P.","year":"2001","journal-title":"APIMIS Suppl."},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00268-002-6541-z","article-title":"Cardiovascular events before and after surgery for primary hyperparathyroidism","volume":"27","author":"Vestergraad P.","year":"2003","journal-title":"World J. Surg."},{"key":"e_1_2_6_9_2","first-page":"887","article-title":"Intima\u2010media thickness measurement of the carotid artery in patients with primary hyperparathyroidism","volume":"20","author":"Lumachi F.","year":"2006","journal-title":"In vivo"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1460643"},{"issue":"2","key":"e_1_2_6_11_2","first-page":"N98","article-title":"Bone densitometry in asymptomatic primary hyperparathyroidism","volume":"17","author":"Miller P.D.","year":"2002","journal-title":"J. Bone Min. 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