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Fibroblast growth factor 23 (FGF\u201023) is a major phosphate\u2010regulating molecule, which can affect both renal and intestinal phosphate uptake to influence overall mineral ion homeostasis. We have found that <jats:italic>Fgf\u201023<\/jats:italic> gene knockout mice (<jats:italic>Fgf\u201023<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic>) develop hyperphosphatemia that consequently leads to abnormal bone mineralization, and severe soft tissue calcifications. On the contrary, <jats:italic>FGF\u201023<\/jats:italic> transgenic mice develop hypophosphatemia and produce rickets\u2010like features in the mutant bone. Further studies using our <jats:italic>Fgf\u201023<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> mice have identified an inverse correlation between Fgf\u201023, and vitamin D or NaPi2a; genomic elimination of either vitamin D or NaPi2a activities from <jats:italic>Fgf\u201023<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> mice could reverse severe hyperphosphatemia to hypophosphatemia, and consequently could alter skeletal mineralization, suggesting that regulation of phosphate homeostasis in <jats:italic>Fgf\u201023<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> mice is vitamin D\u2010 and NaPi2a\u2010mediated process.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1402.021","type":"journal-article","created":{"date-parts":[[2007,12,14]],"date-time":"2007-12-14T19:53:17Z","timestamp":1197661997000},"page":"485-493","source":"Crossref","is-referenced-by-count":5,"title":["Correlation among Hyperphosphatemia, Type II Sodium\u2013Phosphate Transporter Activity, and Vitamin D Metabolism in <i>Fgf\u201023<\/i> Null Mice"],"prefix":"10.1111","volume":"1116","author":[{"given":"DESPINA","family":"SITARA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,12,13]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"1155","volume-title":"Williams Textbook of Endocrinology","author":"Bringhurst F.R.","year":"1998"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2005-0019"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2007.02.002"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114043"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000168"},{"key":"e_1_2_5_7_2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1152\/physrev.1986.66.1.36","article-title":"Cellular mechanisms of inorganic phosphate transport in kidney","volume":"66","author":"Gmaj P.","year":"1986","journal-title":"Physiol. 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