{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:36:35Z","timestamp":1784334995927,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,12,13]],"date-time":"2007-12-13T00:00:00Z","timestamp":1197504000000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract<\/jats:sc>:\u2002<\/jats:bold>  <jats:bold>Parathyroid hormone (PTH) functions as an essential regulator of calcium homeostasis and as a mediator of bone remodeling. We have already shown that PTH stimulates the expression of matrix metalloproteinase\u201013 (MMP\u201013), which is responsible for degrading components of extracellular matrix. We have hypothesized that histone deacetylases (HDACs) are involved with PTH\u2010induced MMP\u201013 gene expression in the osteoblastic cell line, UMR 106\u201301. We have shown that PTH profoundly regulates HDAC4 in UMR 106\u201301 cells through a PKA\u2010dependent pathway, leading to removal of HDAC4 from the MMP\u201013 promoter and its enhanced transcription. Understanding the mechanism of how HDACs affect osteoblast differentiation and mineralization will identify new theraupeutic methods for bone diseases, such as osteoporosis and multiple myeloma.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1402.037","type":"journal-article","created":{"date-parts":[[2007,12,14]],"date-time":"2007-12-14T19:53:17Z","timestamp":1197661997000},"page":"349-353","source":"Crossref","is-referenced-by-count":19,"title":["Parathyroid Hormone Regulates Histone Deacetylases in Osteoblasts"],"prefix":"10.1111","volume":"1116","author":[{"given":"EMI","family":"SHIMIZU","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NAGARAJAN","family":"SELVAMURUGAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JENNIFER J.","family":"WESTENDORF","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NICOLA C.","family":"PARTRIDGE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,12,13]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113275"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1658941"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-120-5-1956"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.7.5037"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80260-3"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80259-7"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80257-3"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2000.5080"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(03)00073-8"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105086200"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.9.1021"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.002"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111871200"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.02.006"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403702200"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.22.7982-7992.2002"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.10.024"},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2007.02.004"},{"key":"e_1_2_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600729"},{"key":"e_1_2_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00429-4"},{"key":"e_1_2_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.19.8456-8464.2005"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1402.037","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1402.037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T05:26:47Z","timestamp":1695619607000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1402.037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["10.1196\/annals.1402.037"],"URL":"https:\/\/doi.org\/10.1196\/annals.1402.037","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}