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Tests with purified hormonal peptide in humans led to the surprising, even paradoxical, finding that PTH can be used pharmacologically to build bone, providing a dramatic therapeutic impact on osteoporosis. These developments plus recent insights into previously unappreciated ligand\u2013receptor conformations that cause prolonged biological activation have stimulated the field of calcium and bone biology and posed new questions about the role of PTH and PTHrP as well as possible new directions in the therapy of osteoporosis and calcium\u2010deficit states.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1402.088","type":"journal-article","created":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T03:33:08Z","timestamp":1196479988000},"page":"196-208","source":"Crossref","is-referenced-by-count":98,"title":["Progress, Paradox, and Potential"],"prefix":"10.1111","volume":"1117","author":[{"given":"JOHN T.","family":"POTTS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"THOMAS J.","family":"GARDELLA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,28]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)69644-9"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.06057"},{"key":"e_1_2_7_4_2","first-page":"94","volume-title":"The Parathyroids","author":"Munson P.L.","year":"1961"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.49.1.145"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)85007-4"},{"key":"e_1_2_7_7_2","first-page":"218","article-title":"The hydrochloric X sicca: a parathyroid preparation for intramuscular injection","volume":"259","author":"Hanson A.M.","year":"1924","journal-title":"Military Surg."},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01527a066"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.67.4.1862"},{"key":"e_1_2_7_10_2","first-page":"1586","article-title":"The amino acid sequence of bovine parathyroid hormone. 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