{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:55:00Z","timestamp":1762541700727},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,12,10]],"date-time":"2007-12-10T00:00:00Z","timestamp":1197244800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>The ability of methylene blue (MB) to inhibit the nitric oxide\u2013induced stimulation of <jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:sc>d<\/jats:sc>\u2010aspartate receptors has been suggested as a possible mechanism of MB's clinical antidepressant action. This study evaluated the alternative\/additional mechanisms of the antidepressant effect of MB on biochemical and behavior levels. Selective inhibition of monoamine oxidase type A (MAO\u2010A) is widely accepted as a major mechanism of the clinical antidepressant effect. MB and the related redox dyes toluidine blue O (TBO), thionine (TN), brilliant cresyl blue (BCB), and toluylene blue (TB) were reversible competitive inhibitors of both MAO\u2010A and MAO\u2010B and were highly selective toward MAO\u2010A. TBO was the most potent inhibitor, followed by TN, BCB, MB, and TB. The dyes studied increased rat pineal <jats:italic>N<\/jats:italic>\u2010acetylserotonin (NAS) and melatonin content, in accordance with our previous observations of the stimulating effect of selective inhibition of MAO\u2010A on pineal melatonin biosynthesis. The redox dyes exerted antidepressant\u2010like activity in frogs; that is, they suppressed the righting reflex in melatonin\u2010primed frogs. This study's results indicate that selective inhibition of MAO\u2010A might mediate the clinical antidepressant effect of MB through NAS stimulation and melatonin biosynthesis.<\/jats:bold><\/jats:p>","DOI":"10.1196\/annals.1403.017","type":"journal-article","created":{"date-parts":[[2007,12,12]],"date-time":"2007-12-12T15:57:47Z","timestamp":1197475067000},"page":"245-252","source":"Crossref","is-referenced-by-count":14,"title":["Effect of Methylene Blue and Related Redox Dyes on Monoamine Oxidase Activity; Rat Pineal Content of <i>N<\/i>\u2010Acetylserotonin, Melatonin, and Related Indoles; and Righting Reflex in Melatonin\u2010Primed Frogs"],"prefix":"10.1111","volume":"1122","author":[{"given":"G.F.","family":"OXENKRUG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.O.","family":"SABLIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.J.","family":"REQUINTINA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,12,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(87)90194-6"},{"key":"e_1_2_6_3_2","first-page":"171","article-title":"Reduction of vanadate by some psychotropic drugs (chlorpromazine, imipramine and dosulepin) and the effect of bleomycine on Na, K\u2010ATPase","volume":"34","author":"Vyskocil F.","year":"1985","journal-title":"Physiol. 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