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The nascent T cell repertoire is exhaustively screened for potential autoreactivity against these ligands presented by mTECs. Failure of this screening process can result in organ\u2010specific autoimmune diseases affecting single or multiple organs. Here we discuss how promiscuous expression of the acetylcholine receptor \u03b1\u2010chain in the human thymus can potentially affect self\u2010tolerance toward this well characterized auto\u2010antigen and thus influence the disease course of myasthenia gravis.<\/jats:p>","DOI":"10.1196\/annals.1405.026","type":"journal-article","created":{"date-parts":[[2008,6,20]],"date-time":"2008-06-20T23:23:28Z","timestamp":1214004208000},"page":"157-162","source":"Crossref","is-referenced-by-count":12,"title":["<i>How Promiscuity Promotes Tolerance: The Case of Myasthenia Gravis<\/i>"],"prefix":"10.1111","volume":"1132","author":[{"given":"Bruno","family":"Kyewski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Taubert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,6,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1436"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115601"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2005.09.022"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2007.04.001"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061864"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700259104"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni906"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1444"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050471"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1075958"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)92118-3"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410220205"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636962"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06066"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/1992\/40576"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2003.11.022"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4598(200102)24:2<203::AID-MUS50>3.0.CO;2-F"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200108)31:8<2476::AID-IMMU2476>3.0.CO;2-T"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070240"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737152"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00253.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.5.1383"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI16584"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0397-293"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0397-289"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.23.12508"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng2068"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200526065"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00417.x"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2137"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1405.026","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1405.026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T02:24:54Z","timestamp":1695695094000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1405.026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1196\/annals.1405.026"],"URL":"https:\/\/doi.org\/10.1196\/annals.1405.026","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}