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We have demonstrated that IVIG administration in experimental autoimmune MG (EAMG) results in suppression of disease that is accompanied by decreased Th1 cell and B cell proliferation. Chromatography of pooled human immunoglobulins (IVIG) on immobilized IgG, isolated from rats with EAMG or from MG patients, results in a depletion of the suppressive activity of the IVIG. Moreover, reconstitution of the activity\u2010depleted IVIG with the eluted minute IVIG fractions that had been adsorbed onto the EAMG\u2010 or MG\u2010specific columns recovers the depleted immunosuppressive activity. This study supports the notion that the therapeutic effect of IVIG is mediated by an antigen\u2010specific anti\u2010immunoglobulin (anti\u2010idiotypic) activity that is <jats:italic>essential<\/jats:italic> for its suppressive activity.<\/jats:p>","DOI":"10.1196\/annals.1405.032","type":"journal-article","created":{"date-parts":[[2008,6,20]],"date-time":"2008-06-20T23:23:28Z","timestamp":1214004208000},"page":"244-248","source":"Crossref","is-referenced-by-count":11,"title":["<i>Immunosuppression of EAMG by IVIG Is Mediated by a Disease\u2010specific Anti\u2010immunoglobulin Fraction<\/i>"],"prefix":"10.1111","volume":"1132","author":[{"given":"Sara","family":"Fuchs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tali","family":"Feferman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Meidler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raanan","family":"Margalit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Sicsic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talma","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orgad","family":"Laub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam C.","family":"Souroujon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,6,28]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra993360"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2004.04.002"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2004.07.046"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0481"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0376"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10205"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90469-0"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)92294-3"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.Suppl.55"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410615"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2006.04.011"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1423.059"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2007.11.020"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.291.5503.484"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.2000.0433"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2005.03.005"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199806)28:06<1823::AID-IMMU1823>3.0.CO;2-F"},{"key":"e_1_2_5_19_2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00401-002-0568-y","article-title":"Effects of intravenous immunoglobulins on T cell and oligodendrocyte apoptosis in high\u2010dose antigen therapy in experimental autoimmune encephalomyelitis","volume":"104","author":"Weishaupt A.","year":"2002","journal-title":"Acta Neuropathol. 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