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Induction of antigenic modulation and complement activation by such autoantibodies leads to ultrastructural damage of the postsynaptic membrane and loss of AChR and associated proteins. Reduction of antigenic modulation by increasing the expression of the receptor\u2010associated anchor protein, rapsyn, or by functionally monovalent competing IgG4 anti\u2010AChR antibodies was shown to prevent MG disease activity. 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