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Biosafety considerations from specimen collection through culture confirmation in the mycology laboratory are critical, as acquisition of coccidioidomycosis by laboratory workers is well documented. The designation of<jats:italic>Coccidioides<\/jats:italic>spp. as select agents of potential bioterrorism has mandated strict regulation of their transport and inventory. The genus appears generally susceptible,<jats:italic>in vitro,<\/jats:italic>although no defined breakpoints exist. 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