{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T02:34:43Z","timestamp":1774924483590,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,10,10]],"date-time":"2007-10-10T00:00:00Z","timestamp":1191974400000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract<\/jats:sc>:\u2002<\/jats:bold>  <jats:bold>In the early years of transplantation in Arizona, coccidioidomycosis occurred in 7% to 9% of recipients, with a mortality rate as high as 72% in some cases. In current transplant programs, however, evolution of immunosuppression and institution of targeted prophylaxis have resulted in coccidioidal infection rates ranging from 1% to 2%. The clinical characteristics of this infection among transplant recipients range from asymptomatic to fulminant and fatal. Dissemination is common, and mortality is high (28%). Because serologic response is often absent or slow, diagnosis can be challenging and often requires invasive diagnostic procedures. Pharmacologic treatment follows the guidelines of the Infectious Diseases Society of America, but control of infection may also dictate a decrease in immunosuppressant treatment. After infection is controlled, secondary azole prophylaxis is recommended to prevent relapse. Patients with a history of coccidioidomycosis may undergo successful transplantation when disease is inactive and azole prophylaxis is instituted. The incidence of donor\u2010derived coccidioidomycosis is not known. The risk of coccidioidal infection among transplant recipients visiting in or relocating to an endemic area is low, and routine prophylaxis for this group is not recommended.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1406.009","type":"journal-article","created":{"date-parts":[[2007,10,17]],"date-time":"2007-10-17T22:34:18Z","timestamp":1192660458000},"page":"365-376","source":"Crossref","is-referenced-by-count":62,"title":["Coccidioidomycosis in Patients Who Have Undergone Transplantation"],"prefix":"10.1111","volume":"1111","author":[{"given":"JANIS E.","family":"BLAIR","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,10]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(02)00040-5"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/323463"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1982.00340160069017"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199306000-00039"},{"key":"e_1_2_8_6_2","unstructured":"Serota A.1996.The efficacy of fluconazole in prevention of coccidioidomycosis following renal transplantation.InCoccidioidomycosis. Proceedings of the 5th International Conference on Coccidioidomycosis; 1994 Aug 24\u201327; Stanford University. H.E. Einstein & A. Catanzaro Eds. :248\u2013264.National Foundation for Infectious Diseases. Washington DC ."},{"key":"e_1_2_8_7_2","first-page":"188","article-title":"Coccidioidomycosis","volume":"17","author":"Galgiani J.N.","year":"1997","journal-title":"Curr. Clin. Top. Infect. Dis."},{"key":"e_1_2_8_8_2","unstructured":"Smithline N. D.A.Ogden A.I.Cohn&K.Johnson.1967.Disseminated coccidioidomycosis in renal transplant patients.InCoccidioidomycosis. Proceedings of the 2nd Coccidioidomycosis Symposium; 1965 Dec 8\u201310; Phoenix AZ.L.Ajello Ed.: 201\u2013206.The University of Arizona Press. Tucson AZ ."},{"key":"e_1_2_8_9_2","first-page":"525","article-title":"Coccidioidomycosis and heart transplantation","volume":"12","author":"Hall K.A.","year":"1993","journal-title":"J. Heart Lung Transplant."},{"key":"e_1_2_8_10_2","unstructured":"Calhoun D.L. 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