{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T05:04:35Z","timestamp":1725080675933},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,10,10]],"date-time":"2007-10-10T00:00:00Z","timestamp":1191974400000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract<\/jats:sc>:\u2002<\/jats:bold>  <jats:bold>\n            <jats:italic>Coccidioides<\/jats:italic> causes coccidioidomycosis in the southwestern United States. Its clinical manifestations range from the primary asymptomatic to progressive pulmonary and extrapulmonary disease. Because of endemicity, frequent relapse, and virulent nature of <jats:italic>Coccidioides<\/jats:italic>, there is an urgent need for the development of effective therapy or vaccine. It has been recognized from studies in human patients and in murine models that the divergence in their susceptibility to <jats:italic>Coccidioides<\/jats:italic> infection is related to differences in T cell response. Dendritic cells (DCs) are most potent antigen\u2010presenting cells that play a critical role in activating na\u00efve T cells. On account of their unique immunostimulatory capacity, DCs have been used for the development of immunotherapy and vaccines against cancer and infectious diseases. We recently investigated the immunostimulatory potential of a DC\u2010based vaccine in a murine model against <jats:italic>Coccidioides posadasii<\/jats:italic> (<jats:italic>C. posadasii<\/jats:italic>). Our results suggest that DCs act as a potent adjuvant and activate protective responses in mice against <jats:italic>C. posadasii<\/jats:italic>.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1406.013","type":"journal-article","created":{"date-parts":[[2007,10,17]],"date-time":"2007-10-17T22:34:18Z","timestamp":1192660458000},"page":"269-274","source":"Crossref","is-referenced-by-count":17,"title":["Dendritic Cell\u2010Based Vaccine against <i>Coccidioides<\/i> Infection"],"prefix":"10.1111","volume":"1111","author":[{"given":"SHANJANA","family":"AWASTHI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,10]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.17.4.804-839.2004"},{"key":"e_1_2_7_3_2","first-page":"47","article-title":"Pleural effusion in Michigan caused by Coccidioides immitis after travel to an endemic area","volume":"37","author":"Hughes C.W.","year":"1989","journal-title":"Henry Ford Hosp. 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