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Gel filtration and anion exchange fractions of thimerosal\u2010inactivated spherules (T27K), when administered with alum adjuvant, also protect mice against lethal respiratory coccidioidal challenge. However, the superb protection afforded by T27K antigens is maintained for some 3 months, but may then diminish. This appears unrelated to the aging of the mice. Prolongation of the protective action may require addition of a different adjuvant or administration of booster doses of vaccine.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1406.016","type":"journal-article","created":{"date-parts":[[2007,10,17]],"date-time":"2007-10-17T22:34:18Z","timestamp":1192660458000},"page":"275-289","source":"Crossref","is-referenced-by-count":12,"title":["Characteristics of the Protective Subcellular Coccidioidal T27K Vaccine"],"prefix":"10.1111","volume":"1111","author":[{"given":"SUZANNE M.","family":"JOHNSON","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KATHLEEN M.","family":"KEREKES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JENNINE M.","family":"LUNETTA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DEMOSTHENES","family":"PAPPAGIANIS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1128\/br.25.3.310-320.1961","article-title":"Human coccidioidomycosis","volume":"25","author":"Smith C.E.","year":"1961","journal-title":"Bact. 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