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Until this time amphotericin B and its lipid congeners have been regarded as the \u201cgold standard\u201d of therapy for severe pulmonary and disseminated coccidioidomycosis. The availability of azoles and later triazoles for the past three decades have relegated the amphotericins into a rescue mode, used mainly in widely disseminated cases, azole intolerance, or when there are contraindications to Azoles, such as pregnancy. In meningitis the intrathecal use of amphotericin B is still used frequently by some clinicians alone or with a triazole. The newer lipid preparations, while more expensive, have significantly reduced toxicity, particularly nephropathy<\/jats:bold>.<\/jats:p>","DOI":"10.1196\/annals.1406.019","type":"journal-article","created":{"date-parts":[[2007,10,17]],"date-time":"2007-10-17T22:34:18Z","timestamp":1192660458000},"page":"434-441","source":"Crossref","is-referenced-by-count":51,"title":["Amphotericin B and Coccidioidomycosis"],"prefix":"10.1111","volume":"1111","author":[{"given":"ROYCE H.","family":"JOHNSON","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HANS E.","family":"EINSTEIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10,10]]},"reference":[{"key":"e_1_2_4_2_2","unstructured":"Fiese M.J.1958.Coccidioidomycosis. 182. 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