{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:00:27Z","timestamp":1777402827320,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T00:00:00Z","timestamp":1228953600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p>Vasopressin (AVP) deficient homozygous Brattleboro rats exhibit severe osmotic challenges due to waterless chronic hypernatremia and hyperosmolality. We investigated the effect of xylazine, an \u03b12\u2010adrenoceptor agonist, on the activity of oxytocinergic (OXY) neurons in the supraoptic nucleus (SON) of homozygous (di\/di), heterozygous (di\/+), and control (+\/+) rats. Ninety minutes after saline (0.1 mL\/100 g b.w., i.p.) or xylazine injection (10 mg\/kg, i.p.) rats were anaesthetized with pentobarbital (50 mg\/kg i.p.) and sacrificed by transcardial perfusion with fixative. Activity of OXY neurons was evidenced by nuclear Fos protein immunoreactivity. Fos\/OXY colabelings were analyzed on 40\u2010\u03bcm thick coronal sections using computerized light microscope. As expected, plasma osmolality and water intake revealed high heterogenity within the di\/di group of rats. Fos expression in SON of di\/di rats was correlated with osmolality of each rat. In saline\u2010treated rats, maximum activation of Fos reached around 4% in +\/+, 20% in di\/+ rats, and as much as 60% in di\/di rats. Xylazine activated in SON about 70% of OXY\u2010ergic neurons in +\/+, 60% in di\/+ rats, and more than 80% in di\/di rats. The present findings indicate that in spite of the high spontaneous activity of SON OXY\u2010ergic neurons due to the AVP deficiency in di\/di rats, many of the silent OXY\u2010ergic neurons in the SON remained acceptable for \u03b12\u2010adrenoceptor stimulation.<\/jats:p>","DOI":"10.1196\/annals.1410.016","type":"journal-article","created":{"date-parts":[[2009,11,6]],"date-time":"2009-11-06T14:56:38Z","timestamp":1257519398000},"page":"154-160","source":"Crossref","is-referenced-by-count":3,"title":["Activity of Oxytocinergic Neurons in the Supraoptic Nucleus under Stimulation of \u03b12\u2010Adrenoceptors in Brattleboro Rats"],"prefix":"10.1196","volume":"1148","author":[{"given":"Jana","family":"Bundzikova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zdeno","family":"Pirnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens D.","family":"Mikkelsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dora","family":"Zelena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Kiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,11]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000124651"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/1961109a0"},{"key":"e_1_2_7_4_2","first-page":"70","article-title":"Oxytocin as an antidiuretic hormone. 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