{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T18:51:33Z","timestamp":1773427893547,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T00:00:00Z","timestamp":1228953600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p>Stress is a well\u2010known factor affecting cardiac contractility through the cardiac sympathetic nerves. A positive inotropic effect of the cardiac sympathetic nerves on the myocardium is reflected by pre\u2010ejection period (PEP) shortening. Patients with Parkinson disease (PD) and neurogenic orthostatic hypotension (NOH) (PD + NOH) or with pure autonomic failure (PAF) have markedly decreased myocardial 6\u2010[<jats:sup>18<\/jats:sup>F]Fluorodopamine\u2010derived radioactivity, reflecting cardiac sympathetic denervation. The functional effects of the cardiac sympathetic denervation have been unknown. We measured PEP and heart rate\u2013corrected PEP (PEPI) responses to i.v. tyramine (1 mg\/min) in 13 patients (9 PD + NOH and 4 PAF) with low 6\u2010[<jats:sup>18<\/jats:sup>F]Fluorodopamine\u2010derived radioactivity and in subjects with normal radioactivity (15 multiple system atrophy with NOS patients (MSA + NOS). Baseline PEP and PEPI did not differ between the groups. By 10 min after initiation of tyramine infusion, PEP and PEPI were significantly lower (<jats:italic>P<\/jats:italic> &lt; 0.01) in MSA + NOS, compared to base line, whereas PEP and PEPI remained unchanged in the PD + NOH\/PAF group. The PEP and PEPI decrease was larger in the MSA + NOS group than in the PD + NOH\/PAF group (<jats:italic>P<\/jats:italic> &lt; 0.05). One of the functional consequences of cardiac sympathetic denervation is failure to increase contractility in response to stimuli that depend on endogenous norepinephrine release.<\/jats:p>","DOI":"10.1196\/annals.1410.066","type":"journal-article","created":{"date-parts":[[2009,11,6]],"date-time":"2009-11-06T14:56:38Z","timestamp":1257519398000},"page":"486-489","source":"Crossref","is-referenced-by-count":18,"title":["Attenuated Pre\u2010ejection Period Response to Tyramine in Patients with Cardiac Sympathetic Denervation"],"prefix":"10.1196","volume":"1148","author":[{"given":"Richard","family":"Imrich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basil A.","family":"Eldadah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oladi","family":"Bentho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Pechnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yehonatan","family":"Sharabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,11]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10559"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.5.1020"},{"key":"e_1_2_7_4_2","first-page":"71","article-title":"Cardiac sympathetic denervation from the early stage of Parkinson's disease: clinical and experimental studies with radiolabeled MIBG","volume":"41","author":"Takatsu H.","year":"2000","journal-title":"J. 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