{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T10:27:23Z","timestamp":1781173643333,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,1,7]],"date-time":"2008-01-07T00:00:00Z","timestamp":1199664000000},"content-version":"vor","delay-in-days":37,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2007,12]]},"abstract":"Abstract<\/jats:sc>:<\/jats:bold> SOX8 is a transcription factor that belongs to the SoxE group of high mobility group (HMG) superfamily of genes. As Sox8<\/jats:italic> is widely expressed during development, and has male\u2010specific expression at the critical period for sex determination, it was initially hypothesized that its inactivation would result in abnormal sex determination. Though knockout males showed normal sexual development, they did however display a progressive seminiferous tubule failure and infertility. Young males could occasionally sire litters, though fecundity decreased with age in parallel with an increase in the degeneration and disorganization of the seminiferous epithelium. SOX8 is a product of the adult Sertoli cells. Sox8<\/jats:italic> knockout males showed a progressive dysregulation of the spermatogenic cycle, including sloughing of spermatocytes and round spermatids into the epididymis and spermiation failure. Sperm that did reach the epididymis showed an age\u2010dependent decrease in both total and progressive motility in addition to overall number. We conclude that SOX8 transactivated genes have key roles in adult Sertoli\u2010cell function and its elimination results in progressive male infertility.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1411.007","type":"journal-article","created":{"date-parts":[[2008,1,9]],"date-time":"2008-01-09T21:02:44Z","timestamp":1199912564000},"page":"104-113","source":"Crossref","is-referenced-by-count":12,"title":["Sox8<\/i> and Sertoli\u2010cell Function"],"prefix":"10.1111","volume":"1120","author":[{"given":"CLAIRE L.","family":"KENNEDY","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PETER","family":"KOOPMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YUJI","family":"MISHINA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MOIRA K.","family":"O'BRYAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,7]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/346245a0"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9883"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01087"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2005.03.010"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.09.014"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2005.06.005"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.20.6951-6959.2001"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1089"},{"key":"e_1_2_4_10_2","doi-asserted-by":"crossref","unstructured":"O'Bryan M. et al.2007.Sox8 is a critical regulator of adult Sertoli cell function and male fertility. unpublished.","DOI":"10.1016\/j.ydbio.2008.01.042"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2005.05.006"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304067200"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101668200"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1137864100"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.102.009811"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmh026"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20513"},{"key":"e_1_2_4_18_2","first-page":"269","volume-title":"The Sertoli Cell","author":"Russell L.","year":"1993"},{"key":"e_1_2_4_19_2","first-page":"63","volume-title":"Germ Cells and Fertilization","author":"Setchell B.P.","year":"1982"},{"key":"e_1_2_4_20_2","volume-title":"Wheaters Functional Histology: A Text and Colour Atlas","author":"Burkitt H.","year":"1993"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(81)90058-0"},{"key":"e_1_2_4_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001480302"},{"key":"e_1_2_4_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl105"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1411.007","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1411.007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T01:05:46Z","timestamp":1695603946000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1411.007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1196\/annals.1411.007"],"URL":"https:\/\/doi.org\/10.1196\/annals.1411.007","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}