{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:49:51Z","timestamp":1762865391390},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,3,19]],"date-time":"2008-03-19T00:00:00Z","timestamp":1205884800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:p>Various conditions were used to investigate the importance of Ca<jats:sup>2+<\/jats:sup> signaling in triggering hypertrophy in neonatal rat cardiomyocytes <jats:italic>in vitro<\/jats:italic>. An increase in cell size and sarcomere reorganization were induced not only by treatment with receptor agonists, such as angiotensin II, aldosterone, and norepinephrine, but also by a small depolarization caused by an increase in the KCl concentration of the medium. This latter treatment has no direct effects on receptor signaling. All these hypertrophic treatments caused a long\u2010lasting increase in the frequency of spontaneous [Ca<jats:sup>2+<\/jats:sup>] oscillations, causing nuclear translocation of transfected NFAT (GFP). Cyclosporine A inhibited hypertrophy and NFAT translocation, but not the increased oscillation frequency. We propose here that calcineurin\u2013NFAT can act as integrators of the Ca<jats:sup>2+<\/jats:sup> signal and can decode alterations in the frequency even of very rapid Ca<jats:sup>2+<\/jats:sup> oscillations.<\/jats:p>","DOI":"10.1196\/annals.1420.008","type":"journal-article","created":{"date-parts":[[2008,3,28]],"date-time":"2008-03-28T21:48:31Z","timestamp":1206740911000},"page":"64-68","source":"Crossref","is-referenced-by-count":17,"title":["<i>Cardiac Cell Hypertrophy<\/i><scp>In Vitro<\/scp>"],"prefix":"10.1111","volume":"1123","author":[{"given":"Matilde","family":"Colella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tullio","family":"Pozzan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,3,19]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.666818"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000120390.68287.BB"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.65.092101.142243"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.9.731"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST0340228"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2006.09.002"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1155"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/383837a0"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/31960"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/31965"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.17.4998"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/81321"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R300023200"},{"key":"e_1_2_7_15_2","unstructured":"Colella M.et al.2007.Calcineurin and NFAT as Ca2+signal integrators in cardiomyocyte hypertrophy. In preparation."}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1420.008","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1420.008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:46:19Z","timestamp":1695689179000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1420.008"}},"subtitle":["<i>Role of Calcineurin\/NFAT as Ca<sup>2+<\/sup> Signal Integrators<\/i>"],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1196\/annals.1420.008"],"URL":"https:\/\/doi.org\/10.1196\/annals.1420.008","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}