{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:26:28Z","timestamp":1788326788354,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,8,29]],"date-time":"2007-08-29T00:00:00Z","timestamp":1188345600000},"content-version":"vor","delay-in-days":89,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract<\/jats:sc>:\u2002<\/jats:bold>  <jats:bold>Photosensitivity is a widely known characteristic of both cutaneous and systemic lupus erythematosus (LE). However, sun\u2010induced organ involvement is rarely reported in LE. We describe a 34\u2010year\u2010old woman who had been in complete remission of systemic LE for more than 8 years without treatment. After sunbathing, she developed acute sunburn followed by cutaneous LE in sun\u2010exposed areas. Six weeks later, a lupus nephritis was diagnosed and high serum levels of anti\u2010double\u2010stranded (ds) DNA and anti\u2010Ro\/SSA antibodies were detected. Treatment with systemic cyclophosphamide and prednisolone led to septicemia requiring assisted ventilation for more than 2 weeks and repeated hemodialysis. Clinical remission was achieved 3 months later by the use of prednisolone and mycophenolate mofetile. Meanwhile, mild proteinuria persisted, anti\u2010dsDNA antibodies normalized. We hypothesize that the sunburn\u2010induced keratinocyte necrosis\/apoptosis exposed intracellular antigens as trigger for the generation of autoantibodies that finally mediated immune\u2010complex nephritis. The patient highlights the impact of UV light not only on skin but also on internal organ involvement in LE.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1422.004","type":"journal-article","created":{"date-parts":[[2007,10,16]],"date-time":"2007-10-16T22:43:07Z","timestamp":1192574587000},"page":"35-40","source":"Crossref","is-referenced-by-count":56,"title":["Sun\u2010Induced Life\u2010Threatening Lupus Nephritis"],"prefix":"10.1111","volume":"1108","author":[{"given":"ENNO","family":"SCHMIDT","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HANS\u2010PETER","family":"TONY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EVA\u2010BETTINA","family":"BR\u00d6CKER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTIAN","family":"KNEITZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,8,29]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05379.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2004.00094.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1965.01600110069013"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(81)80261-7"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70497-9"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.9.1175"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021933"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/08916930500285394"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.4.1317"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115922"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.11.5778"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00118.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.3.340"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1191\/0961203305lu2054oa"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1191\/096120398678919976"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0832411100"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1422.004","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1422.004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T03:06:19Z","timestamp":1695697579000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1422.004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1196\/annals.1422.004"],"URL":"https:\/\/doi.org\/10.1196\/annals.1422.004","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}