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Among established risk factors for CV disease, smoking may exert a more dangerous effect on arterial wall in RA than in the general population by a synergic effect with inflammatory processes of the disease. Although persistent inflammation and immune dysregulation of RA may contribute to favor other well\u2010known CV risk factors, such as dyslipidemia, it is now clear that the disease itself represents an independent risk factor for CV disease by the action of RA chronic inflammatory process as well as humoral and cell\u2010mediated immune mechanisms. There is evidence that CV risk is associated with severity and extension of the disease and it is of interest the fact that the presence of circulating anticyclic citrullinated peptide antibodies appears to be associated with stronger evidence of subclinical atherosclerosis in RA.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1422.038","type":"journal-article","created":{"date-parts":[[2007,10,16]],"date-time":"2007-10-16T22:43:07Z","timestamp":1192574587000},"page":"372-381","source":"Crossref","is-referenced-by-count":32,"title":["Precocious Atherosclerosis in Rheumatoid Arthritis"],"prefix":"10.1111","volume":"1108","author":[{"given":"ROBERTO","family":"GERLI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YANIV","family":"SHERER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELENA BARTOLONI","family":"BOCCI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GAETANO","family":"VAUDO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHEILA","family":"MOSCATELLI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YEHUDA","family":"SHOENFELD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,29]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.507996"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1191\/0961203305lu2199oa"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000054612.26458.B2"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.018101"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20853"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200112)44:12<2737::AID-ART460>3.0.CO;2-#"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2098"},{"key":"e_1_2_6_9_2","first-page":"2425","article-title":"Metabolic syndrome and subclinical atherosclerosis in rheumatoid arthritis","volume":"33","author":"Dessein P.H.","year":"2006","journal-title":"J. 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