{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:58:25Z","timestamp":1792803505881,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,8,29]],"date-time":"2007-08-29T00:00:00Z","timestamp":1188345600000},"content-version":"vor","delay-in-days":89,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract<\/jats:sc>:\u2002<\/jats:bold>  <jats:bold>Infections can act as environmental triggers inducing or promoting autoimmune disease in genetically predisposed individuals. Identification of microbial peptides similar to self\u2010tissues may by molecular mimicry, provide the inducing mechanism for an immune response. The aim of this study was to identify autoantibodies (autoAbs) in nonautoimmune individuals during acute bacterial, viral, or parasitic infections. Specific Abs or specific infections with an increased autoAb load may shed insight into the mechanisms of autoimmune disease. Sera from 88 patients with acute infections (41 bacterial, 23 viral, 17 parasitic, and 7 rickettsial) were tested by the ELISA method for antinuclear antibodies (ANA) 8 Pro, and Abs to thyroid peroxidase (TPO), thyroglobulin, phospholipids, annexin\u2010V, laminin, anti\u2013<jats:italic>Saccharomyces cervisiae<\/jats:italic> (ASCA), and prothrombin, along with 80 normal controls. Elevated titers of Abs to annexin\u2010V and prothrombin were the most prevalent in viral, parasitic, and rickettsial infections and to laminin in viral and parasitic infections. Elevated titers of ASCA and ANA were found in viral and bacterial infections. Antiphospholipid Abs were found in parasitic and Q\u2010fever infections. Thirty\u2010four individuals harbored elevated titers of at least two Abs. An autoAb burden was detected in individuals with hepatitis A, hepatitis B, toxoplasma or Q\u2010fever infections. In nonautoimmune individuals with various (bacterial, viral, parasitic, and rickettsial) infections, elevated titers of Abs to annexin\u2010V, prothrombin, laminin, ASCA, ANA, and phospholipids were most frequently detected.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1422.061","type":"journal-article","created":{"date-parts":[[2007,10,16]],"date-time":"2007-10-16T22:43:07Z","timestamp":1192574587000},"page":"584-593","source":"Crossref","is-referenced-by-count":63,"title":["Autoantibodies in Nonautoimmune Individuals during Infections"],"prefix":"10.1111","volume":"1108","author":[{"given":"TATIANA","family":"BERLIN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GISELE","family":"ZANDMAN\u2010GODDARD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MIRI","family":"BLANK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TORSTEN","family":"MATTHIAS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SASCHA","family":"PFEIFFER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"INGRID","family":"WEIS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ELIAS","family":"TOUBI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SHAM","family":"SINGH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RONALD","family":"ASHERSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ABIGAIL","family":"FRASER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BORIS","family":"GILBURD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TAL","family":"SAPIR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YAIR","family":"LEVY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JANJA","family":"LUKA\u010c","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BLA\u017d","family":"ROZMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TANJA","family":"KVEDER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YEHUDA","family":"SHOENFELD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,8,29]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/08916930500285352"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2003.09.005"},{"key":"e_1_2_5_4_2","first-page":"422","article-title":"2004","volume":"25","author":"Portis T.","journal-title":"Trends Immunol."},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.80440-0"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.014175"},{"key":"e_1_2_5_7_2","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1172\/JCI0212337","article-title":"Bacterial induction of autoantibodies to beta\u20102\u2010glycoprotein\u2010I accounts for the infectious etiology of antiphospholipid syndrome","volume":"109","author":"Blank M.","year":"2002","journal-title":"J. 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