{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T17:50:47Z","timestamp":1718646647992},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,9,27]],"date-time":"2007-09-27T00:00:00Z","timestamp":1190851200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract<\/jats:sc>:\u2002<\/jats:bold>  <jats:bold>As suggested by concordance rates in twins, genetic factors are critical to the susceptibility and progression of primary biliary cirrhosis (PBC). Among cytokines, transforming growth factor beta\u20101 (TGF\u2010\u03b21) plays an important role in autoimmunity and liver fibrosis and a TGF\u2010\u03b21 receptor knockout mouse has been recently proposed as a model for PBC. The promoter region of the TGF\u2010\u03b21 gene has two single nucleotide polymorphisms (SNPs) at positions \u2212800 and \u2212509, which influence serum concentrations of latent and active TGF\u2010\u03b21. We studied genomic DNA from 65 Japanese patients with PBC and 71 matched healthy controls for the association of TGF\u2010\u03b21 SNPs analyzed by polymerase chain reaction\u2013restriction fragment length polymorphism (PCR\u2013RFLP) with susceptibility and disease progression of PBC. The \u2212800 G to A SNP was not found in the Japanese population and no significant difference in the distribution of TGF\u2010\u03b21 promoter gene \u2212509 SNP was found between PBC cases and controls. Further, TGF\u2010\u03b21 genotypes failed to correlate with clinical parameters, including histological stage and prognostic score. In conclusion, the TGF\u2010\u03b21 promoter gene SNPs are not associated with disease susceptibility or progression in Japanese patients with PBC.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1423.003","type":"journal-article","created":{"date-parts":[[2007,10,2]],"date-time":"2007-10-02T20:20:20Z","timestamp":1191356420000},"page":"15-22","source":"Crossref","is-referenced-by-count":8,"title":["Genetic Polymorphisms of Transforming Growth Factor \u03b2\u20101 Promoter and Primary Biliary Cirrhosis in Japanese Patients"],"prefix":"10.1111","volume":"1110","author":[{"given":"KENTARO","family":"KIKUCHI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ATSUSHI","family":"TANAKA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MASANAO","family":"MATSUSHITA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ERIKO","family":"KITAZAWA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NAOMI","family":"HOSOYA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUMI","family":"KAWASHIMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CARLO","family":"SELMI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. ERIC","family":"GERSHWIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIROSHI","family":"MIYAKAWA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,9,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0528.2002.017402.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.05.005"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80135-4"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.3.397"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/0891693021000056703"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1254.017"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007105"},{"key":"e_1_2_6_9_2","first-page":"933","article-title":"1991","volume":"324","author":"Castilla A.","journal-title":"N. Engl. J. Med."},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411103311907"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2002.02672.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/15.7.3188"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.1.93"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043898"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)31272-3"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840200120"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/003591576706001205"},{"key":"e_1_2_6_18_2","first-page":"2006","article-title":"Anti\u2010mitochondrial antibodies and primary biliary cirrhosis in T6F\u2010beta receptor II dominant negative mice","volume":"177","author":"Oertelt S.","journal-title":"J. Immunol"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.28.5.881"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1998.tb03089.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.031732"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00440-3"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1423.003","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1423.003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T08:52:38Z","timestamp":1695631958000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1423.003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1196\/annals.1423.003"],"URL":"https:\/\/doi.org\/10.1196\/annals.1423.003","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}