{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:03:43Z","timestamp":1761743023091},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,9,27]],"date-time":"2007-09-27T00:00:00Z","timestamp":1190851200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract<\/jats:sc>:\u2002<\/jats:bold>  <jats:bold>Polymorphisms of the peptidylarginine deiminase 4 (<jats:italic>PADI4<\/jats:italic>) gene encoding for the isoenzyme that converts arginyl into citrullyl residues have been shown to contribute to susceptibility to rheumatoid arthritis (RA), depending on the population studied. We aimed at determining whether <jats:italic>PADI4<\/jats:italic> single nucleotide polymorphisms (SNPs) are associated with RA in a Hungarian population. The relationship between anticyclic citrullinated peptide (anti\u2010CCP) production and <jats:italic>HLA\u2010DRB1<\/jats:italic> alleles encoding the shared epitope (SE) was also investigated. DNA samples were obtained from RA (<jats:italic>n<\/jats:italic>= 261) patients and from control donors (<jats:italic>n<\/jats:italic>= 120). <jats:italic>HLA\u2010DRB1<\/jats:italic> genotyping was carried out by polymerase chain reaction (PCR) with sequence\u2010specific priming. PAD4_92 G\/C and PAD4_104 T\/C SNPs were genotyped using real\u2010time PCR allele discrimination. Autoantibodies against CCP were detected by ELISA. All healthy controls tested anti\u2010CCP negative, whereas 171 (66%) RA patients were anti\u2010CCP positive. No significant difference in allele or genotype frequencies were found between RA patients and controls for any of the <jats:italic>PADI4<\/jats:italic> SNPs. Anti\u2010CCP seropositivity was unrelated to these two SNPs. No association was found between any of the <jats:italic>PADI4<\/jats:italic> SNPs and <jats:italic>HLA\u2010DRB1<\/jats:italic> subtypes. Presence of the <jats:italic>HLA\u2010RB1<\/jats:italic> SE alleles was significantly associated with anti\u2010CCP seropositivity; <jats:italic>HLA\u2010DRB1*0401<\/jats:italic> and <jats:italic>HLA\u2010DRB1*1001<\/jats:italic> carriers showed the strongest association. In conclusion, our data suggest that polymorphisms of the <jats:italic>PADI4<\/jats:italic> gene are not associated with rheumatoid arthritis and are unlikely to be responsible for the presence of anti\u2010CCP autoantibodies in a white Hungarian population. <jats:italic>HLA\u2010DRB1<\/jats:italic> SE alleles, however, may significantly contribute to the genetic determination of anti\u2010CCP production in Hungarian patients with RA.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1423.004","type":"journal-article","created":{"date-parts":[[2007,10,2]],"date-time":"2007-10-02T20:20:20Z","timestamp":1191356420000},"page":"23-32","source":"Crossref","is-referenced-by-count":29,"title":["Genetic Background of Anticyclic Citrullinated Peptide Autoantibody Production in Hungarian Patients with Rheumatoid Arthritis"],"prefix":"10.1111","volume":"1110","author":[{"given":"GYULA","family":"PO\u00d3R","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZSOLT B.","family":"NAGY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZSUZSANNA","family":"SCHMIDT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00c1RTA","family":"BR\u00d3ZIK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KATALIN","family":"MER\u00c9TEY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"P\u00c9TER","family":"GERGELY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,9,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1206"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.051391"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar1697"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21739"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21385"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21309"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21536"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar1889"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei008"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.026831"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh614"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20169"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/498651"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22206"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei023"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20431"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel023"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.2.538"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22373"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21575"},{"key":"e_1_2_6_23_2","first-page":"1363","article-title":"HLA\u2010DRB1 and DQB typing of Hispanic American patients with rheumatoid arthritis: the \u201cshared epitope\u201d hypothesis may not apply","volume":"23","author":"Teller K.","year":"1996","journal-title":"J. Rheumatol."},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1361.067"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1556\/AMicr.50.2003.1.4"},{"key":"e_1_2_6_26_2","first-page":"2019","article-title":"Prognostic factors in rheumatoid arthritis","volume":"143","author":"Rojkovich B.","year":"2002","journal-title":"Orv. Hetil."},{"key":"e_1_2_6_27_2","first-page":"71","article-title":"Lack of anti\u2010cyclic citrullinated peptide autoantibody and HLA\u2010DRB1*0401 might partly explain the benign synovitis in polymyalgia rheumatica [abstract]","volume":"65","author":"Schmidt Z.","year":"2006","journal-title":"Ann. Rheum. Dis."},{"key":"e_1_2_6_28_2","first-page":"2007","article-title":"Influence of human leucocyte antigen\u2010DRB1 on the susceptibility to rheumatoid arthritis and on the production of anti\u2010cyclic citrullinated peptide antibodies in a Portuguese population","volume":"66","author":"Ligeiro D.","journal-title":"Ann. Rheum. 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