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We have demonstrated that IVIG administration in experimental autoimmune MG (EAMG) results in suppression of disease that is accompanied by decreased Th1 cell and B cell proliferation. Chromatography of pooled human immunoglobulins (IVIGs) on immobilized IgG, isolated from rats with EAMG, results in a complete depletion of the suppressive activity of the IVIG. Moreover, the eluate from this EAMG\u2010specific antibody column retains the immunosuppressive activity of IVIG. This study supports the notion that the therapeutic effect of IVIGs is mediated by an antigen\u2010specific anti\u2010immunoglobulin (anti\u2010idiotypic) activity that is essential for its suppressive activity.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1423.059","type":"journal-article","created":{"date-parts":[[2007,10,2]],"date-time":"2007-10-02T20:20:20Z","timestamp":1191356420000},"page":"550-558","source":"Crossref","is-referenced-by-count":7,"title":["Suppression of Experimental Autoimmune Myasthenia Gravis by Intravenous Immunoglobulin and Isolation of a Disease\u2010Specific IgG Fraction"],"prefix":"10.1111","volume":"1110","author":[{"given":"SARA","family":"FUCHS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TALI","family":"FEFERMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAI\u2010YUN","family":"ZHU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROBERTO","family":"MEIDLER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RAANAN","family":"MARGALIT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NINGSHAN","family":"WANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ORGAD","family":"LAUB","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MIRIAM C.","family":"SOUROUJON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,9,27]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra993360"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2004.04.002"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2004.07.046"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.291.5503.484"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199806)28:06<1823::AID-IMMU1823>3.0.CO;2-F"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.2000.0433"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2005.03.005"},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00401-002-0568-y","article-title":"Effects of intravenous immunoglobulins on T cell and oligodendrocyte apoptosis in high\u2010dose antigen therapy in experimental autoimmune encephalomyelitis","volume":"104","author":"Weishaupt A.","year":"2002","journal-title":"Acta Neuropathol. 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